• Version:
  • 11.0 [archived version]
STRINGSTRING
LRRC37A2 LRRC37A2 GART GART PARD3B PARD3B PPCS PPCS FRMD4A FRMD4A DCAKD DCAKD PPCDC PPCDC PANK4 PANK4 LRRC37A LRRC37A PLBD2 PLBD2 AIP AIP
"DCAKD" - dephospho-CoA kinase domain containing in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
DCAKDdephospho-CoA kinase domain containing (231 aa)    
Predicted Functional Partners:
PPCDC
Phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4’- phosphopantotheine (204 aa)
   
 
  0.715
PPCS
Phosphopantothenate--cysteine ligase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine; Belongs to the PPC synthetase family (311 aa)
   
 
  0.698
LRRC37A2
Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2 (1700 aa)
           
  0.668
FRMD4A
FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing (1039 aa)
           
  0.662
PARD3B
Partitioning defective 3 homolog B; Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions; Belongs to the PAR3 family (1143 aa)
           
  0.654
PANK4
Pantothenate kinase 4; Plays a role in the physiological regulation of the intracellular CoA concentration (773 aa)
     
 
  0.642
GART
Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family (1010 aa)
   
   
  0.636
PLBD2
Putative phospholipase B-like 2; Putative phospholipase (589 aa)
           
  0.628
LRRC37A
Leucine-rich repeat-containing protein 37A; Leucine rich repeat containing 37A (1700 aa)
           
  0.558
AIP
AH receptor-interacting protein; May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting; FKBP prolyl isomerases (330 aa)
     
   
  0.547
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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