node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC42EP2 | EHBP1L1 | ENSP00000279249 | ENSP00000312671 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner; Belongs to the BORG/CEP family | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing | 0.684 |
CDC42EP2 | FAM89B | ENSP00000279249 | ENSP00000431459 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner; Belongs to the BORG/CEP family | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | 0.754 |
CDC42EP2 | FRMD8 | ENSP00000279249 | ENSP00000319726 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner; Belongs to the BORG/CEP family | FERM domain containing 8 | 0.693 |
CDC42EP2 | KCNK7 | ENSP00000279249 | ENSP00000344820 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner; Belongs to the BORG/CEP family | Potassium channel subfamily K member 7; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family | 0.631 |
CDC42EP2 | SSSCA1 | ENSP00000279249 | ENSP00000312318 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner; Belongs to the BORG/CEP family | Sjoegren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies | 0.755 |
CDC42EP2 | TIGD3 | ENSP00000279249 | ENSP00000308354 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner; Belongs to the BORG/CEP family | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.710 |
CLHC1 | TIGD3 | ENSP00000384869 | ENSP00000308354 | Clathrin heavy chain linker domain containing 1 | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.630 |
CTPS1 | CTPS2 | ENSP00000361704 | ENSP00000401264 | CTP synthase 1; This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity; Glutamine amidotransferase like class 1 domain containing | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | 0.988 |
CTPS1 | TIGD3 | ENSP00000361704 | ENSP00000308354 | CTP synthase 1; This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity; Glutamine amidotransferase like class 1 domain containing | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.888 |
CTPS2 | CTPS1 | ENSP00000401264 | ENSP00000361704 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | CTP synthase 1; This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity; Glutamine amidotransferase like class 1 domain containing | 0.988 |
CTPS2 | TIGD3 | ENSP00000401264 | ENSP00000308354 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.933 |
EHBP1L1 | CDC42EP2 | ENSP00000312671 | ENSP00000279249 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner; Belongs to the BORG/CEP family | 0.684 |
EHBP1L1 | FAM89B | ENSP00000312671 | ENSP00000431459 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | 0.688 |
EHBP1L1 | FRMD8 | ENSP00000312671 | ENSP00000319726 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing | FERM domain containing 8 | 0.786 |
EHBP1L1 | KCNK7 | ENSP00000312671 | ENSP00000344820 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing | Potassium channel subfamily K member 7; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family | 0.710 |
EHBP1L1 | SSSCA1 | ENSP00000312671 | ENSP00000312318 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing | Sjoegren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies | 0.769 |
EHBP1L1 | TIGD3 | ENSP00000312671 | ENSP00000308354 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.769 |
FAM89B | CDC42EP2 | ENSP00000431459 | ENSP00000279249 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner; Belongs to the BORG/CEP family | 0.754 |
FAM89B | EHBP1L1 | ENSP00000431459 | ENSP00000312671 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing | 0.688 |
FAM89B | FRMD8 | ENSP00000431459 | ENSP00000319726 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | FERM domain containing 8 | 0.815 |