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  • 11.0 [archived version]
STRINGSTRING
CTTN CTTN FGF3 FGF3 C19orf48 C19orf48 ORAOV1 ORAOV1 C20orf166 C20orf166 TPCN2 TPCN2 MYEOV MYEOV MRGPRF MRGPRF KLK3 KLK3 CNN1 CNN1 TOP1 TOP1
"MYEOV" - Myeloma-overexpressed gene protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYEOVMyeloma-overexpressed gene protein; Myeloma overexpressed (313 aa)    
Predicted Functional Partners:
CNN1
Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity) (297 aa)
        
      0.685
ORAOV1
Oral cancer overexpressed 1 (137 aa)
            
  0.678
C20orf166
Uncharacterized protein MIR1-1HG; Chromosome 20 open reading frame 166 (117 aa)
            
  0.661
CTTN
Src substrate cortactin; Cortactin (634 aa)
            
  0.647
C19orf48
Uncharacterized protein C19orf48; Chromosome 19 open reading frame 48; Minor histocompatibility antigens (117 aa)
            
  0.609
TPCN2
Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily (752 aa)
            
  0.559
KLK3
Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins (261 aa)
            
  0.532
FGF3
Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development; Belongs to the heparin-binding growth factors family (239 aa)
            
  0.530
TOP1
DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5’-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus remov [...] (765 aa)
            
  0.529
MRGPRF
Mas-related G-protein coupled receptor member F; Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); G protein-coupled receptors, Class A orphans (343 aa)
            
  0.518
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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