node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B3GALT2 | FAM229B | ENSP00000356404 | ENSP00000357645 | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family | 0.667 |
B3GALT2 | IQCF1 | ENSP00000356404 | ENSP00000307958 | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | 0.545 |
B3GALT2 | OR2AK2 | ENSP00000356404 | ENSP00000355436 | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | Olfactory receptor 2AK2; Odorant receptor; Olfactory receptors, family 2 | 0.426 |
B3GALT2 | TMEM60 | ENSP00000356404 | ENSP00000257663 | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | Transmembrane protein 60 | 0.487 |
CELF6 | IQCF1 | ENSP00000287202 | ENSP00000307958 | CUGBP Elav-like family member 6; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA; Belongs to the CELF/BRUNOL family | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | 0.538 |
CELF6 | RASL10B | ENSP00000287202 | ENSP00000474230 | CUGBP Elav-like family member 6; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA; Belongs to the CELF/BRUNOL family | Ras-like protein family member 10B; May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure; Belongs to the small GTPase superfamily. Ras family | 0.403 |
FAM229B | B3GALT2 | ENSP00000357645 | ENSP00000356404 | Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | 0.667 |
FAM229B | IQCF1 | ENSP00000357645 | ENSP00000307958 | Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | 0.799 |
FAM229B | OR2AK2 | ENSP00000357645 | ENSP00000355436 | Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family | Olfactory receptor 2AK2; Odorant receptor; Olfactory receptors, family 2 | 0.700 |
FAM229B | TMEM60 | ENSP00000357645 | ENSP00000257663 | Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family | Transmembrane protein 60 | 0.780 |
FAR2 | IQCF1 | ENSP00000443291 | ENSP00000307958 | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity) | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | 0.594 |
IQCF1 | B3GALT2 | ENSP00000307958 | ENSP00000356404 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | 0.545 |
IQCF1 | CELF6 | ENSP00000307958 | ENSP00000287202 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | CUGBP Elav-like family member 6; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA; Belongs to the CELF/BRUNOL family | 0.538 |
IQCF1 | FAM229B | ENSP00000307958 | ENSP00000357645 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family | 0.799 |
IQCF1 | FAR2 | ENSP00000307958 | ENSP00000443291 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity) | 0.594 |
IQCF1 | MUL1 | ENSP00000307958 | ENSP00000264198 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at ’Lys-284’ involving ’Lys-48’-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the con [...] | 0.713 |
IQCF1 | OR2AK2 | ENSP00000307958 | ENSP00000355436 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | Olfactory receptor 2AK2; Odorant receptor; Olfactory receptors, family 2 | 0.589 |
IQCF1 | PACS1 | ENSP00000307958 | ENSP00000316454 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | Phosphofurin acidic cluster sorting protein 1; Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN; Belongs to the PACS family | 0.795 |
IQCF1 | RASL10B | ENSP00000307958 | ENSP00000474230 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | Ras-like protein family member 10B; May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure; Belongs to the small GTPase superfamily. Ras family | 0.572 |
IQCF1 | SDR42E2 | ENSP00000307958 | ENSP00000473474 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction | Short chain dehydrogenase/reductase family 42E, member 2; Belongs to the 3-beta-HSD family | 0.545 |