• Version:
  • 11.0 [archived version]
STRINGSTRING
MUL1 MUL1 FAR2 FAR2 B3GALT2 B3GALT2 FAM229B FAM229B SDR42E2 SDR42E2 IQCF1 IQCF1 OR2AK2 OR2AK2 TMEM60 TMEM60 RASL10B RASL10B CELF6 CELF6 PACS1 PACS1
"IQCF1" - IQ domain-containing protein F1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IQCF1IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction (205 aa)    
Predicted Functional Partners:
FAM229B
Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family (80 aa)
           
  0.799
PACS1
Phosphofurin acidic cluster sorting protein 1; Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN; Belongs to the PACS family (963 aa)
       
      0.795
MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at ’Lys-284’ involving ’Lys-48’-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the con [...] (352 aa)
       
      0.713
TMEM60
Transmembrane protein 60 (133 aa)
           
  0.707
FAR2
Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity) (515 aa)
       
      0.594
OR2AK2
Olfactory receptor 2AK2; Odorant receptor; Olfactory receptors, family 2 (335 aa)
           
  0.589
RASL10B
Ras-like protein family member 10B; May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure; Belongs to the small GTPase superfamily. Ras family (203 aa)
           
  0.572
B3GALT2
Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues (422 aa)
           
  0.545
SDR42E2
Short chain dehydrogenase/reductase family 42E, member 2; Belongs to the 3-beta-HSD family (422 aa)
           
  0.545
CELF6
CUGBP Elav-like family member 6; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA; Belongs to the CELF/BRUNOL family (481 aa)
           
  0.538
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]