• Version:
  • 11.0 [archived version]
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RPL4 RPL4 RPLP0 RPLP0 RPS4X RPS4X RPS6 RPS6 RPS8 RPS8 RPS5 RPS5 EEF2 EEF2 RPL8 RPL8 RPL5 RPL5 RPL3 RPL3 RPS2 RPS2
"EEF2" - Elongation factor 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEF2Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily (858 aa)    
Predicted Functional Partners:
RPL8
60S ribosomal protein L8; Component of the large ribosomal subunit (257 aa)
 
  0.999
RPS5
Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family (204 aa)
   
  0.999
RPL4
L ribosomal proteins (427 aa)
   
  0.999
RPS2
Ribosomal protein S2 (293 aa)
 
  0.999
RPS6
40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; S ribosomal proteins (249 aa)
     
  0.999
RPLP0
60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (317 aa)
   
  0.999
RPS8
Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family (208 aa)
     
  0.999
RPL3
60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; L ribosomal proteins (403 aa)
 
  0.999
RPS4X
Ribosomal protein S4, X-linked; Belongs to the eukaryotic ribosomal protein eS4 family (263 aa)
   
  0.999
RPL5
60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa)
   
  0.999
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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