| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC67 | HMP19 | ENSP00000298050 | ENSP00000307722 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | 0.503 |
| CCDC67 | MAMDC2 | ENSP00000298050 | ENSP00000366387 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | MAM domain containing 2 | 0.487 |
| CCDC67 | RBM47 | ENSP00000298050 | ENSP00000371212 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | 0.401 |
| CCDC67 | ZMAT4 | ENSP00000298050 | ENSP00000297737 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | Zinc finger matrin-type 4 | 0.504 |
| CDC6 | HMP19 | ENSP00000209728 | ENSP00000307722 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | 0.539 |
| CDC6 | PPP1R9B | ENSP00000209728 | ENSP00000478767 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | Neurabin-2; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Pla [...] | 0.438 |
| CDC6 | TRIP12 | ENSP00000209728 | ENSP00000373696 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...] | 0.584 |
| CELSR1 | HMP19 | ENSP00000262738 | ENSP00000307722 | Cadherin EGF LAG seven-pass G-type receptor 1; Receptor that may have an important role in cell/cell signaling during nervous system formation; Adhesion G protein-coupled receptors, subfamily C | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | 0.400 |
| HMP19 | CCDC67 | ENSP00000307722 | ENSP00000298050 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | 0.503 |
| HMP19 | CDC6 | ENSP00000307722 | ENSP00000209728 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.539 |
| HMP19 | CELSR1 | ENSP00000307722 | ENSP00000262738 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | Cadherin EGF LAG seven-pass G-type receptor 1; Receptor that may have an important role in cell/cell signaling during nervous system formation; Adhesion G protein-coupled receptors, subfamily C | 0.400 |
| HMP19 | KIF5A | ENSP00000307722 | ENSP00000408979 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | Kinesin heavy chain isoform 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily | 0.415 |
| HMP19 | MAMDC2 | ENSP00000307722 | ENSP00000366387 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | MAM domain containing 2 | 0.493 |
| HMP19 | PPP1R9B | ENSP00000307722 | ENSP00000478767 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | Neurabin-2; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Pla [...] | 0.529 |
| HMP19 | RBM47 | ENSP00000307722 | ENSP00000371212 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | 0.400 |
| HMP19 | RRH | ENSP00000307722 | ENSP00000314992 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | Visual pigment-like receptor peropsin; May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds; Opsin receptors | 0.539 |
| HMP19 | TRIP12 | ENSP00000307722 | ENSP00000373696 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...] | 0.572 |
| HMP19 | ZMAT4 | ENSP00000307722 | ENSP00000297737 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | Zinc finger matrin-type 4 | 0.509 |
| KIF5A | HMP19 | ENSP00000408979 | ENSP00000307722 | Kinesin heavy chain isoform 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 | 0.415 |
| MAMDC2 | CCDC67 | ENSP00000366387 | ENSP00000298050 | MAM domain containing 2 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | 0.487 |
