TSPAN5 protein (human) - STRING database

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TSPAN5

Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins (268 aa)

Predicted Functional Partners:

ERICH3

0.826

ADAM10

0.731

METAP1

0.657

C1orf68

0.623

ITGB1

0.547

TMEM14C

0.540

SBSN

0.536

TSPAN32

0.528

TSPAN31

0.513

DUOX2

0.507

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	TSPAN5	ENSP00000260408	ENSP00000307701	Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at ’76-Ala-\|-Val-77’ to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cle [...]	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.731
C1orf68	DUOX2	ENSP00000357764	ENSP00000475084	Skin-specific protein 32; Chromosome 1 open reading frame 68	Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain	0.537
C1orf68	SBSN	ENSP00000357764	ENSP00000430242	Skin-specific protein 32; Chromosome 1 open reading frame 68	Suprabasin	0.566
C1orf68	TMEM14C	ENSP00000357764	ENSP00000444561	Skin-specific protein 32; Chromosome 1 open reading frame 68	Transmembrane protein 14C; Required for normal heme biosynthesis	0.533
C1orf68	TSPAN5	ENSP00000357764	ENSP00000307701	Skin-specific protein 32; Chromosome 1 open reading frame 68	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.623
DUOX2	C1orf68	ENSP00000475084	ENSP00000357764	Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain	Skin-specific protein 32; Chromosome 1 open reading frame 68	0.537
DUOX2	SBSN	ENSP00000475084	ENSP00000430242	Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain	Suprabasin	0.474
DUOX2	TSPAN5	ENSP00000475084	ENSP00000307701	Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.507
ERICH3	TSPAN5	ENSP00000322609	ENSP00000307701	Glutamate-rich protein 3; Glutamate rich 3	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.826
ITGB1	TSPAN5	ENSP00000379350	ENSP00000307701	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.547
METAP1	TSPAN5	ENSP00000296411	ENSP00000307701	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.657
SBSN	C1orf68	ENSP00000430242	ENSP00000357764	Suprabasin	Skin-specific protein 32; Chromosome 1 open reading frame 68	0.566
SBSN	DUOX2	ENSP00000430242	ENSP00000475084	Suprabasin	Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain	0.474
SBSN	TMEM14C	ENSP00000430242	ENSP00000444561	Suprabasin	Transmembrane protein 14C; Required for normal heme biosynthesis	0.463
SBSN	TSPAN5	ENSP00000430242	ENSP00000307701	Suprabasin	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.536
TMEM14C	C1orf68	ENSP00000444561	ENSP00000357764	Transmembrane protein 14C; Required for normal heme biosynthesis	Skin-specific protein 32; Chromosome 1 open reading frame 68	0.533
TMEM14C	SBSN	ENSP00000444561	ENSP00000430242	Transmembrane protein 14C; Required for normal heme biosynthesis	Suprabasin	0.463
TMEM14C	TSPAN5	ENSP00000444561	ENSP00000307701	Transmembrane protein 14C; Required for normal heme biosynthesis	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.540
TSPAN31	TSPAN32	ENSP00000257910	ENSP00000182290	Tetraspanin-31; Tetraspanin 31; Tetraspanins	Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family	0.493
TSPAN31	TSPAN5	ENSP00000257910	ENSP00000307701	Tetraspanin-31; Tetraspanin 31; Tetraspanins	Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins	0.513

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