| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC93 | COMMD9 | ENSP00000365477 | ENSP00000263401 | Coiled-coil domain-containing protein 93; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits | 0.918 |
| CCDC93 | MORN4 | ENSP00000365477 | ENSP00000307636 | Coiled-coil domain-containing protein 93; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | 0.650 |
| COMMD9 | CCDC93 | ENSP00000263401 | ENSP00000365477 | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits | Coiled-coil domain-containing protein 93; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C | 0.918 |
| COMMD9 | MFAP3 | ENSP00000263401 | ENSP00000322956 | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits | Microfibril-associated glycoprotein 3; Component of the elastin-associated microfibrils; I-set domain containing | 0.520 |
| COMMD9 | MORN4 | ENSP00000263401 | ENSP00000307636 | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | 0.575 |
| KIF26B | MORN4 | ENSP00000385545 | ENSP00000307636 | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. K [...] | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | 0.583 |
| KIF26B | MYO3B | ENSP00000385545 | ENSP00000386213 | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. K [...] | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filame [...] | 0.674 |
| KIF26B | PCDHB3 | ENSP00000385545 | ENSP00000231130 | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. K [...] | Protocadherin beta-3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.590 |
| MFAP3 | COMMD9 | ENSP00000322956 | ENSP00000263401 | Microfibril-associated glycoprotein 3; Component of the elastin-associated microfibrils; I-set domain containing | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits | 0.520 |
| MFAP3 | MORN4 | ENSP00000322956 | ENSP00000307636 | Microfibril-associated glycoprotein 3; Component of the elastin-associated microfibrils; I-set domain containing | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | 0.584 |
| MORN2 | MORN4 | ENSP00000386563 | ENSP00000307636 | MORN repeat-containing protein 2; Might have a role in spermatogenesis | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | 0.730 |
| MORN2 | MORN5 | ENSP00000386563 | ENSP00000362869 | MORN repeat-containing protein 2; Might have a role in spermatogenesis | MORN repeat containing 5 | 0.561 |
| MORN4 | CCDC93 | ENSP00000307636 | ENSP00000365477 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | Coiled-coil domain-containing protein 93; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C | 0.650 |
| MORN4 | COMMD9 | ENSP00000307636 | ENSP00000263401 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits | 0.575 |
| MORN4 | KIF26B | ENSP00000307636 | ENSP00000385545 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. K [...] | 0.583 |
| MORN4 | MFAP3 | ENSP00000307636 | ENSP00000322956 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | Microfibril-associated glycoprotein 3; Component of the elastin-associated microfibrils; I-set domain containing | 0.584 |
| MORN4 | MORN2 | ENSP00000307636 | ENSP00000386563 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | MORN repeat-containing protein 2; Might have a role in spermatogenesis | 0.730 |
| MORN4 | MORN5 | ENSP00000307636 | ENSP00000362869 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | MORN repeat containing 5 | 0.755 |
| MORN4 | MYO19 | ENSP00000307636 | ENSP00000479518 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | Unconventional myosin-XIX; Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis. May be involved in mitochondrial transport or positioning; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.753 |
| MORN4 | MYO3A | ENSP00000307636 | ENSP00000265944 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory [...] | 0.862 |
