• Version:
  • 11.0 [archived version]
STRINGSTRING
MRPS31 MRPS31 ACTRT2 ACTRT2 SAAL1 SAAL1 OR4D10 OR4D10 NKG7 NKG7 ZBTB5 ZBTB5 CCDC39 CCDC39 CSDC2 CSDC2 TMCC1 TMCC1 MESDC1 MESDC1 TMEM181 TMEM181
"ZBTB5" - Zinc finger and BTB domain-containing protein 5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZBTB5Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation; BTB domain containing (677 aa)    
Predicted Functional Partners:
SAAL1
Protein SAAL1; Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli; Armadillo-like helical domain containing (474 aa)
           
  0.686
ACTRT2
Actin related protein T2 (377 aa)
     
 
  0.602
OR4D10
Olfactory receptor 4D10; Odorant receptor; Olfactory receptors, family 4 (311 aa)
           
  0.594
TMCC1
Transmembrane and coiled-coil domain containing (653 aa)
           
  0.556
MESDC1
Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells (362 aa)
           
  0.555
TMEM181
Transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication (612 aa)
           
  0.531
CCDC39
Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (941 aa)
     
   
  0.528
NKG7
Protein NKG7; Natural killer cell granule protein 7; Belongs to the PMP-22/EMP/MP20 family (165 aa)
           
  0.521
MRPS31
Mitochondrial ribosomal protein S31 (395 aa)
           
  0.517
CSDC2
Cold shock domain-containing protein C2; RNA-binding factor which binds specifically to the very 3’-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity) (153 aa)
       
 
  0.508
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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