| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACSS1 | CST2 | ENSP00000316924 | ENSP00000307540 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | 0.455 |
| BST2 | CST2 | ENSP00000252593 | ENSP00000307540 | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae- h [...] | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | 0.641 |
| C1orf198 | CST2 | ENSP00000355623 | ENSP00000307540 | Uncharacterized protein C1orf198; Chromosome 1 open reading frame 198 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | 0.568 |
| CPPED1 | CST2 | ENSP00000371193 | ENSP00000307540 | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | 0.804 |
| CST2 | ACSS1 | ENSP00000307540 | ENSP00000316924 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.455 |
| CST2 | BST2 | ENSP00000307540 | ENSP00000252593 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae- h [...] | 0.641 |
| CST2 | C1orf198 | ENSP00000307540 | ENSP00000355623 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Uncharacterized protein C1orf198; Chromosome 1 open reading frame 198 | 0.568 |
| CST2 | CPPED1 | ENSP00000307540 | ENSP00000371193 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family | 0.804 |
| CST2 | CSTA | ENSP00000307540 | ENSP00000264474 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family | 0.599 |
| CST2 | CSTB | ENSP00000307540 | ENSP00000291568 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | 0.581 |
| CST2 | CTSB | ENSP00000307540 | ENSP00000345672 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | 0.605 |
| CST2 | CTSL | ENSP00000307540 | ENSP00000345344 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Cathepsin L1; Important for the overall degradation of proteins in lysosomes; Cathepsins | 0.507 |
| CST2 | LCN1 | ENSP00000307540 | ENSP00000263598 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | 0.474 |
| CST2 | LGMN | ENSP00000307540 | ENSP00000376911 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | Legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system; Belongs to the peptidase C13 family | 0.505 |
| CSTA | CST2 | ENSP00000264474 | ENSP00000307540 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | 0.599 |
| CSTA | CTSB | ENSP00000264474 | ENSP00000345672 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | 0.977 |
| CSTA | CTSL | ENSP00000264474 | ENSP00000345344 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family | Cathepsin L1; Important for the overall degradation of proteins in lysosomes; Cathepsins | 0.952 |
| CSTA | LCN1 | ENSP00000264474 | ENSP00000263598 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | 0.430 |
| CSTB | CST2 | ENSP00000291568 | ENSP00000307540 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 | 0.581 |
| CSTB | CTSB | ENSP00000291568 | ENSP00000345672 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins | 0.829 |
