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  • 11.0 [archived version]
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KRT5 KRT5 RBFOX3 RBFOX3 NPY NPY TH TH CALB2 CALB2 SST SST PVALB PVALB GAD2 GAD2 GAD1 GAD1 CCK CCK CHAT CHAT
"CALB2" - Calretinin in Homo sapiens
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CALB2Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing (271 aa)    
Predicted Functional Partners:
PVALB
Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing (110 aa)
     
   
  0.944
SST
Somatostatin; Somatostatin inhibits the release of somatotropin; Endogenous ligands (116 aa)
     
   
  0.857
GAD1
Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family (594 aa)
     
 
  0.827
TH
Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family (528 aa)
     
   
  0.796
NPY
Pro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family (97 aa)
     
   
  0.790
CCK
Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Endogenous ligands (115 aa)
     
   
  0.769
GAD2
Glutamate decarboxylase 2; Catalyzes the production of GABA (585 aa)
     
 
  0.766
KRT5
Keratin, type II cytoskeletal 5; Keratins, type II (590 aa)
           
  0.764
RBFOX3
RNA binding protein fox-1 homolog 3; Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD); RNA binding motif containing (312 aa)
     
   
  0.759
CHAT
Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase family (748 aa)
     
   
  0.752
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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