| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKDD1A | CCDC135 | ENSP00000325895 | ENSP00000353942 | Ankyrin repeat and death domain containing 1A | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | 0.750 |
| ANKDD1A | FHL3 | ENSP00000325895 | ENSP00000362107 | Ankyrin repeat and death domain containing 1A | Four and a half LIM domains 3 | 0.676 |
| ANKDD1A | RASSF4 | ENSP00000325895 | ENSP00000339692 | Ankyrin repeat and death domain containing 1A | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | 0.483 |
| ANKDD1A | SHE | ENSP00000325895 | ENSP00000307369 | Ankyrin repeat and death domain containing 1A | SH2 domain-containing adapter protein E; Src homology 2 domain containing E | 0.463 |
| CCDC135 | ANKDD1A | ENSP00000353942 | ENSP00000325895 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Ankyrin repeat and death domain containing 1A | 0.750 |
| CCDC135 | FHL3 | ENSP00000353942 | ENSP00000362107 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Four and a half LIM domains 3 | 0.621 |
| CCDC135 | RASSF4 | ENSP00000353942 | ENSP00000339692 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | 0.466 |
| CCDC135 | SHE | ENSP00000353942 | ENSP00000307369 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | SH2 domain-containing adapter protein E; Src homology 2 domain containing E | 0.471 |
| ETFA | SHE | ENSP00000452762 | ENSP00000307369 | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism | SH2 domain-containing adapter protein E; Src homology 2 domain containing E | 0.511 |
| FHL3 | ANKDD1A | ENSP00000362107 | ENSP00000325895 | Four and a half LIM domains 3 | Ankyrin repeat and death domain containing 1A | 0.676 |
| FHL3 | CCDC135 | ENSP00000362107 | ENSP00000353942 | Four and a half LIM domains 3 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | 0.621 |
| FHL3 | RASSF4 | ENSP00000362107 | ENSP00000339692 | Four and a half LIM domains 3 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | 0.404 |
| FHL3 | SHE | ENSP00000362107 | ENSP00000307369 | Four and a half LIM domains 3 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E | 0.474 |
| IMPACT | SHE | ENSP00000284202 | ENSP00000307369 | Protein IMPACT; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1- mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 a [...] | SH2 domain-containing adapter protein E; Src homology 2 domain containing E | 0.468 |
| NEU4 | SHE | ENSP00000320318 | ENSP00000307369 | Sialidase-4; May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2’-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids | SH2 domain-containing adapter protein E; Src homology 2 domain containing E | 0.557 |
| NONO | SHE | ENSP00000276079 | ENSP00000307369 | Non-POU domain-containing octamer-binding protein; DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3’ side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclea [...] | SH2 domain-containing adapter protein E; Src homology 2 domain containing E | 0.443 |
| NOTO | SHE | ENSP00000381486 | ENSP00000307369 | Homeobox protein notochord; Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity); NKL subclass homeoboxes and pseudogenes | SH2 domain-containing adapter protein E; Src homology 2 domain containing E | 0.527 |
| RASSF4 | ANKDD1A | ENSP00000339692 | ENSP00000325895 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | Ankyrin repeat and death domain containing 1A | 0.483 |
| RASSF4 | CCDC135 | ENSP00000339692 | ENSP00000353942 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family | 0.466 |
| RASSF4 | FHL3 | ENSP00000339692 | ENSP00000362107 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | Four and a half LIM domains 3 | 0.404 |
