| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C11orf24 | CCDC115 | ENSP00000307264 | ENSP00000259229 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.652 |
| C11orf24 | CDC14B | ENSP00000307264 | ENSP00000364389 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint- following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases; Belongs to the protein-tyrosine ph [...] | 0.484 |
| C11orf24 | CREBL2 | ENSP00000307264 | ENSP00000228865 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily | 0.534 |
| C11orf24 | ENSG00000259316 | ENSP00000307264 | ENSP00000475686 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | Casein kinase I isoform gamma-1 | 0.472 |
| C11orf24 | GPR152 | ENSP00000307264 | ENSP00000310255 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | Probable G-protein coupled receptor 152; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.453 |
| C11orf24 | KIAA1549 | ENSP00000307264 | ENSP00000416040 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | UPF0606 protein KIAA1549; KIAA1549 | 0.444 |
| C11orf24 | MED8 | ENSP00000307264 | ENSP00000290663 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a targe [...] | 0.463 |
| C11orf24 | TMEM109 | ENSP00000307264 | ENSP00000227525 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.520 |
| C11orf24 | ZNF367 | ENSP00000307264 | ENSP00000364405 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes; Zinc fingers C2H2-type | 0.448 |
| C11orf24 | ZNF616 | ENSP00000307264 | ENSP00000471000 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | Zinc finger protein 616; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.528 |
| CCDC115 | C11orf24 | ENSP00000259229 | ENSP00000307264 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | 0.652 |
| CCDC115 | CREBL2 | ENSP00000259229 | ENSP00000228865 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily | 0.576 |
| CCDC115 | KIAA1549 | ENSP00000259229 | ENSP00000416040 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | UPF0606 protein KIAA1549; KIAA1549 | 0.500 |
| CCDC115 | MED8 | ENSP00000259229 | ENSP00000290663 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a targe [...] | 0.502 |
| CCDC115 | TMEM109 | ENSP00000259229 | ENSP00000227525 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity) | 0.529 |
| CCDC115 | ZNF367 | ENSP00000259229 | ENSP00000364405 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes; Zinc fingers C2H2-type | 0.414 |
| CCDC115 | ZNF616 | ENSP00000259229 | ENSP00000471000 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | Zinc finger protein 616; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.473 |
| CDC14B | C11orf24 | ENSP00000364389 | ENSP00000307264 | Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint- following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases; Belongs to the protein-tyrosine ph [...] | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | 0.484 |
| CDC14B | ZNF616 | ENSP00000364389 | ENSP00000471000 | Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint- following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases; Belongs to the protein-tyrosine ph [...] | Zinc finger protein 616; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.441 |
| CREBL2 | C11orf24 | ENSP00000228865 | ENSP00000307264 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 | 0.534 |
