VASN protein (human) - STRING database

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VASN

Vasorin; May act as an inhibitor of TGF-beta signaling (673 aa)

Predicted Functional Partners:

CDC5L

0.983

TGFB3

0.766

TGFB2

0.718

LPHN3

0.685

LPHN1

0.685

LPHN2

0.685

UBE2I

0.600

ISLR2

0.597

TGFB1

0.597

LCE4A

0.581

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC5L	VASN	ENSP00000360532	ENSP00000306864	Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing	Vasorin; May act as an inhibitor of TGF-beta signaling	0.983
ISLR2	LPHN1	ENSP00000355402	ENSP00000340688	Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	0.685
ISLR2	LPHN2	ENSP00000355402	ENSP00000322270	Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	0.685
ISLR2	LPHN3	ENSP00000355402	ENSP00000422533	Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	0.685
ISLR2	VASN	ENSP00000355402	ENSP00000306864	Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing	Vasorin; May act as an inhibitor of TGF-beta signaling	0.597
LCE4A	VASN	ENSP00000357766	ENSP00000306864	Late cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family	Vasorin; May act as an inhibitor of TGF-beta signaling	0.581
LPHN1	ISLR2	ENSP00000340688	ENSP00000355402	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing	0.685
LPHN1	VASN	ENSP00000340688	ENSP00000306864	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	Vasorin; May act as an inhibitor of TGF-beta signaling	0.685
LPHN2	ISLR2	ENSP00000322270	ENSP00000355402	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing	0.685
LPHN2	VASN	ENSP00000322270	ENSP00000306864	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Vasorin; May act as an inhibitor of TGF-beta signaling	0.685
LPHN3	ISLR2	ENSP00000422533	ENSP00000355402	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing	0.685
LPHN3	VASN	ENSP00000422533	ENSP00000306864	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	Vasorin; May act as an inhibitor of TGF-beta signaling	0.685
TGFB1	TGFB2	ENSP00000221930	ENSP00000355896	Transforming growth factor beta-1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysi [...]	Transforming growth factor beta-2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth; Endogenous ligands	0.934
TGFB1	TGFB3	ENSP00000221930	ENSP00000238682	Transforming growth factor beta-1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysi [...]	Transforming growth factor beta-3; Involved in embryogenesis and cell differentiation; Belongs to the TGF-beta family	0.906
TGFB1	VASN	ENSP00000221930	ENSP00000306864	Transforming growth factor beta-1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysi [...]	Vasorin; May act as an inhibitor of TGF-beta signaling	0.597
TGFB2	TGFB1	ENSP00000355896	ENSP00000221930	Transforming growth factor beta-2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth; Endogenous ligands	Transforming growth factor beta-1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysi [...]	0.934
TGFB2	TGFB3	ENSP00000355896	ENSP00000238682	Transforming growth factor beta-2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth; Endogenous ligands	Transforming growth factor beta-3; Involved in embryogenesis and cell differentiation; Belongs to the TGF-beta family	0.936
TGFB2	VASN	ENSP00000355896	ENSP00000306864	Transforming growth factor beta-2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth; Endogenous ligands	Vasorin; May act as an inhibitor of TGF-beta signaling	0.718
TGFB3	TGFB1	ENSP00000238682	ENSP00000221930	Transforming growth factor beta-3; Involved in embryogenesis and cell differentiation; Belongs to the TGF-beta family	Transforming growth factor beta-1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysi [...]	0.906
TGFB3	TGFB2	ENSP00000238682	ENSP00000355896	Transforming growth factor beta-3; Involved in embryogenesis and cell differentiation; Belongs to the TGF-beta family	Transforming growth factor beta-2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth; Endogenous ligands	0.936

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