| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKK1 | CHRNA5 | ENSP00000306678 | ENSP00000299565 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | 0.668 |
| ANKK1 | COMT | ENSP00000306678 | ENSP00000354511 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | 0.738 |
| ANKK1 | DRD2 | ENSP00000306678 | ENSP00000354859 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family | 0.903 |
| ANKK1 | DRD4 | ENSP00000306678 | ENSP00000176183 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | 0.738 |
| ANKK1 | GABRA2 | ENSP00000306678 | ENSP00000421828 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Gamma-aminobutyric acid receptor subunit alpha-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.643 |
| ANKK1 | NCAM1 | ENSP00000306678 | ENSP00000480132 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc; CD molecules | 0.671 |
| ANKK1 | PDZD7 | ENSP00000306678 | ENSP00000480489 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | PDZ domain-containing protein 7; Deafness associated genes | 0.803 |
| ANKK1 | SLC6A3 | ENSP00000306678 | ENSP00000270349 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals; Solute carriers | 0.677 |
| ANKK1 | SLC6A4 | ENSP00000306678 | ENSP00000261707 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily | 0.647 |
| ANKK1 | TTC12 | ENSP00000306678 | ENSP00000433757 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | Tetratricopeptide repeat domain containing | 0.926 |
| CHRNA5 | ANKK1 | ENSP00000299565 | ENSP00000306678 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | 0.668 |
| CHRNA5 | COMT | ENSP00000299565 | ENSP00000354511 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | 0.444 |
| CHRNA5 | DRD2 | ENSP00000299565 | ENSP00000354859 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family | 0.547 |
| CHRNA5 | SLC6A4 | ENSP00000299565 | ENSP00000261707 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily | 0.448 |
| CHRNA5 | TTC12 | ENSP00000299565 | ENSP00000433757 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | Tetratricopeptide repeat domain containing | 0.606 |
| COMT | ANKK1 | ENSP00000354511 | ENSP00000306678 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family | 0.738 |
| COMT | CHRNA5 | ENSP00000354511 | ENSP00000299565 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | 0.444 |
| COMT | DRD2 | ENSP00000354511 | ENSP00000354859 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family | 0.865 |
| COMT | DRD4 | ENSP00000354511 | ENSP00000176183 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | 0.869 |
| COMT | GABRA2 | ENSP00000354511 | ENSP00000421828 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | Gamma-aminobutyric acid receptor subunit alpha-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.602 |
