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STRINGSTRING
ZBTB46 ZBTB46 CER1 CER1 USPL1 USPL1 PES1 PES1 C1orf101 C1orf101 DESI2 DESI2 EFCAB2 EFCAB2 HELB HELB MIS18A MIS18A FBXO21 FBXO21 DOK2 DOK2
"DESI2" - Desumoylating isopeptidase 2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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DESI2Desumoylating isopeptidase 2; Protease which may deconjugate SUMO from some substrate proteins; Desumoylating isopeptidases (194 aa)    
Predicted Functional Partners:
C1orf101
Cation channel sperm-associated protein subunit epsilon; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Belongs to the CATSPERD family (951 aa)
            
  0.775
ZBTB46
Zinc finger and BTB domain-containing protein 46; Function as a transcriptional repressor for PRDM1; BTB domain containing (589 aa)
            
  0.742
USPL1
SUMO-specific isopeptidase USPL1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. Plays a key role in RNA polymerase-II- mediated snRNA transcription in the Cajal bodies. Is a component of complexes that can bind to U snRNA genes (1092 aa)
            
  0.714
EFCAB2
EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated (162 aa)
      
   
  0.666
HELB
DNA helicase B; 5’-3’ DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5’-3’ ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5’-3’ polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP [...] (1087 aa)
      
   
  0.653
MIS18A
Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (233 aa)
      
   
  0.590
PES1
Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family (588 aa)
      
   
  0.564
DOK2
Docking protein 2; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) (412 aa)
            
  0.553
FBXO21
F-box only protein 21; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other (628 aa)
            
  0.526
CER1
Cerberus; Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity); Belongs to the DAN family (267 aa)
            
  0.519
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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