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STRINGSTRING
UBE2G1 UBE2G1 PARK2 PARK2 APLNR APLNR GPR37 GPR37 NPY NPY APP APP PSAP PSAP HTR5A HTR5A GNAI1 GNAI1 DRD2 DRD2 GNAI2 GNAI2
"GPR37" - Prosaposin receptor GPR37 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GPR37Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G-protein coupled receptor 1 family (613 aa)    
Predicted Functional Partners:
PARK2
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as ’Lys-6’, ’Lys-11’, ’Lys-48’-linked and ’Lys-63’-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating ’Lys-63’-linked polyubiquitination of misf [...] (465 aa)
        
  0.980
HTR5A
5-hydroxytryptamine receptor 5A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins; 5-hydroxytryptamine receptors, G protein-coupled (357 aa)
      
 
  0.969
PSAP
Prosaposin; Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases; Endogenous ligands (524 aa)
          
  0.951
APLNR
Apelin receptor; Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure by acting as a receptor for APLN hormone; Belongs to the G-protein coupled receptor 1 family (380 aa)
      
 
  0.948
NPY
Pro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family (97 aa)
      
 
  0.939
GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase- they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (355 aa)
        
  0.931
GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
      
  0.928
APP
Amyloid-beta A4 protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6); Endogenous ligands (770 aa)
      
 
  0.926
DRD2
D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family (443 aa)
      
 
0.926
UBE2G1
Ubiquitin-conjugating enzyme E2 G1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-, as well as ’Lys-63’-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4; Ubiquitin conjugating enzymes E2 (170 aa)
          
  0.925
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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