• Version:
  • 11.0 [archived version]
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CCDC39 CCDC39 TMEM186 TMEM186 CCDC40 CCDC40 CCDC151 CCDC151 ARMC4 ARMC4 TMEM143 TMEM143 DNAI1 DNAI1 ZMYND10 ZMYND10 DNAH5 DNAH5 CCDC114 CCDC114 DYX1C1 DYX1C1
"ARMC4" - Armadillo repeat-containing protein 4 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ARMC4Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing (1044 aa)    
Predicted Functional Partners:
CCDC151
Coiled-coil domain-containing protein 151; Ciliary protein involved in outer dynein arm assembly and required for motile cilia function (595 aa)
     
   
  0.902
CCDC114
Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms; Belongs to the ODA1/DCC2 family (670 aa)
     
   
  0.844
ZMYND10
Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins; Belongs to the ZMYND10 family (440 aa)
     
   
  0.820
CCDC39
Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (941 aa)
     
   
  0.805
DNAH5
Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles; Dyneins, axonemal (4624 aa)
     
   
  0.776
DYX1C1
Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (420 aa)
     
 
  0.753
DNAI1
Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family (703 aa)
     
   
  0.751
CCDC40
Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family (1142 aa)
     
   
  0.751
TMEM186
Transmembrane protein 186 (213 aa)
           
  0.748
TMEM143
Transmembrane protein 143 (459 aa)
           
  0.741
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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