| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAD11 | ISOC1 | ENSP00000264990 | ENSP00000173527 | Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA | Isochorismatase domain containing 1 | 0.539 |
| ACAD11 | TMEM135 | ENSP00000264990 | ENSP00000306344 | Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.610 |
| ACAD11 | ZADH2 | ENSP00000264990 | ENSP00000323678 | Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA | Prostaglandin reductase 3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily | 0.651 |
| CCDC67 | TMEM135 | ENSP00000298050 | ENSP00000306344 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.583 |
| CTDSPL2 | CXorf57 | ENSP00000260327 | ENSP00000361628 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | 0.599 |
| CTDSPL2 | FAM49B | ENSP00000260327 | ENSP00000429150 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | Protein FAM49B; Family with sequence similarity 49 member B | 0.607 |
| CTDSPL2 | TMEM135 | ENSP00000260327 | ENSP00000306344 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.674 |
| CTDSPL2 | ZCCHC10 | ENSP00000260327 | ENSP00000423276 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | Zinc finger CCHC-type containing 10 | 0.707 |
| CXorf57 | CTDSPL2 | ENSP00000361628 | ENSP00000260327 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | 0.599 |
| CXorf57 | FAM49B | ENSP00000361628 | ENSP00000429150 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | Protein FAM49B; Family with sequence similarity 49 member B | 0.537 |
| CXorf57 | TMEM135 | ENSP00000361628 | ENSP00000306344 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.605 |
| CXorf57 | ZCCHC10 | ENSP00000361628 | ENSP00000423276 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | Zinc finger CCHC-type containing 10 | 0.625 |
| FAM49B | CTDSPL2 | ENSP00000429150 | ENSP00000260327 | Protein FAM49B; Family with sequence similarity 49 member B | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases | 0.607 |
| FAM49B | CXorf57 | ENSP00000429150 | ENSP00000361628 | Protein FAM49B; Family with sequence similarity 49 member B | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks | 0.537 |
| FAM49B | TMEM135 | ENSP00000429150 | ENSP00000306344 | Protein FAM49B; Family with sequence similarity 49 member B | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.611 |
| FAM49B | ZCCHC10 | ENSP00000429150 | ENSP00000423276 | Protein FAM49B; Family with sequence similarity 49 member B | Zinc finger CCHC-type containing 10 | 0.676 |
| GPATCH1 | TMEM135 | ENSP00000170564 | ENSP00000306344 | G-patch domain containing 1; Belongs to the GPATCH1 family | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.623 |
| ISOC1 | ACAD11 | ENSP00000173527 | ENSP00000264990 | Isochorismatase domain containing 1 | Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA | 0.539 |
| ISOC1 | TMEM135 | ENSP00000173527 | ENSP00000306344 | Isochorismatase domain containing 1 | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family | 0.565 |
| ISOC1 | ZADH2 | ENSP00000173527 | ENSP00000323678 | Isochorismatase domain containing 1 | Prostaglandin reductase 3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily | 0.561 |
