KRT78 protein (human) - STRING database

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KRT78

Keratin, type II cytoskeletal 78; Keratins, type II (520 aa)

Predicted Functional Partners:

KPRP

0.963

KRT16

0.940

KRT14

0.938

KRT19

0.934

KRT32

0.932

KRT15

0.932

KRT17

0.931

KRT35

0.930

KRT36

0.930

KRT27

0.929

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KPRP	KRT78	ENSP00000475216	ENSP00000306261	Keratinocyte proline rich protein	Keratin, type II cytoskeletal 78; Keratins, type II	0.963
KRT14	KRT15	ENSP00000167586	ENSP00000254043	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 15; Keratins, type I	0.934
KRT14	KRT16	ENSP00000167586	ENSP00000301653	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance	0.967
KRT14	KRT17	ENSP00000167586	ENSP00000308452	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...]	0.963
KRT14	KRT19	ENSP00000167586	ENSP00000355124	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type I	0.908
KRT14	KRT27	ENSP00000167586	ENSP00000301656	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs)	0.903
KRT14	KRT32	ENSP00000167586	ENSP00000225899	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family	0.904
KRT14	KRT35	ENSP00000167586	ENSP00000377558	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cuticular Ha5; Keratins, type I	0.900
KRT14	KRT36	ENSP00000167586	ENSP00000329165	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type I cuticular Ha6; Keratins, type I	0.900
KRT14	KRT78	ENSP00000167586	ENSP00000306261	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	Keratin, type II cytoskeletal 78; Keratins, type II	0.938
KRT15	KRT14	ENSP00000254043	ENSP00000167586	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	0.934
KRT15	KRT16	ENSP00000254043	ENSP00000301653	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance	0.916
KRT15	KRT17	ENSP00000254043	ENSP00000308452	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...]	0.922
KRT15	KRT19	ENSP00000254043	ENSP00000355124	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type I	0.922
KRT15	KRT27	ENSP00000254043	ENSP00000301656	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs)	0.901
KRT15	KRT32	ENSP00000254043	ENSP00000225899	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family	0.907
KRT15	KRT35	ENSP00000254043	ENSP00000377558	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cuticular Ha5; Keratins, type I	0.902
KRT15	KRT36	ENSP00000254043	ENSP00000329165	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type I cuticular Ha6; Keratins, type I	0.903
KRT15	KRT78	ENSP00000254043	ENSP00000306261	Keratin, type I cytoskeletal 15; Keratins, type I	Keratin, type II cytoskeletal 78; Keratins, type II	0.932
KRT16	KRT14	ENSP00000301653	ENSP00000167586	Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance	Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro	0.967

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