node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANTXR1 | ANTXR2 | ENSP00000301945 | ENSP00000306185 | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.906 |
ANTXR1 | FURIN | ENSP00000301945 | ENSP00000483552 | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | Furin; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif; Proprotein convertase subtilisin/kexin family | 0.966 |
ANTXR1 | GOLPH3 | ENSP00000301945 | ENSP00000265070 | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through inter [...] | 0.518 |
ANTXR1 | LRP6 | ENSP00000301945 | ENSP00000261349 | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | Low-density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...] | 0.680 |
ANTXR2 | ANTXR1 | ENSP00000306185 | ENSP00000301945 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | 0.906 |
ANTXR2 | BAMBI | ENSP00000306185 | ENSP00000364683 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | 0.582 |
ANTXR2 | BICD1 | ENSP00000306185 | ENSP00000281474 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex; Belongs to the BicD family | 0.621 |
ANTXR2 | DCBLD2 | ENSP00000306185 | ENSP00000321573 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Discoidin, CUB and LCCL domain containing 2 | 0.607 |
ANTXR2 | ERAP1 | ENSP00000306185 | ENSP00000296754 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Endoplasmic reticulum aminopeptidase 1; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play [...] | 0.577 |
ANTXR2 | FURIN | ENSP00000306185 | ENSP00000483552 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Furin; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif; Proprotein convertase subtilisin/kexin family | 0.969 |
ANTXR2 | GOLPH3 | ENSP00000306185 | ENSP00000265070 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through inter [...] | 0.594 |
ANTXR2 | LRFN5 | ENSP00000306185 | ENSP00000298119 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Leucine-rich repeat and fibronectin type-III domain-containing protein 5; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons; Belongs to the LRFN family | 0.581 |
ANTXR2 | LRP6 | ENSP00000306185 | ENSP00000261349 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Low-density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...] | 0.774 |
ANTXR2 | SCUBE1 | ENSP00000306185 | ENSP00000354080 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology | 0.665 |
BAMBI | ANTXR2 | ENSP00000364683 | ENSP00000306185 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.582 |
BAMBI | DCBLD2 | ENSP00000364683 | ENSP00000321573 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Discoidin, CUB and LCCL domain containing 2 | 0.630 |
BAMBI | LRP6 | ENSP00000364683 | ENSP00000261349 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Low-density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...] | 0.886 |
BICD1 | ANTXR2 | ENSP00000281474 | ENSP00000306185 | Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex; Belongs to the BicD family | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.621 |
DCBLD2 | ANTXR2 | ENSP00000321573 | ENSP00000306185 | Discoidin, CUB and LCCL domain containing 2 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.607 |
DCBLD2 | BAMBI | ENSP00000321573 | ENSP00000364683 | Discoidin, CUB and LCCL domain containing 2 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | 0.630 |