HTRA4 protein (human) - STRING database

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HTRA4

Serine protease HTRA4; Serine protease; PDZ domain containing (476 aa)

Predicted Functional Partners:

TM4SF19

0.730

PRSS58

0.724

PRSS1

0.716

TM2D2

0.609

SMEK1

0.595

PAPPA2

0.555

LEPROTL1

0.549

LETM2

0.546

PLEKHA2

0.538

KCNMB3

0.526

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HTRA4	KCNMB3	ENSP00000305919	ENSP00000319370	Serine protease HTRA4; Serine protease; PDZ domain containing	Calcium-activated potassium channel subunit beta-3; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of [...]	0.526
HTRA4	LEPROTL1	ENSP00000305919	ENSP00000428281	Serine protease HTRA4; Serine protease; PDZ domain containing	Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family	0.549
HTRA4	LETM2	ENSP00000305919	ENSP00000369291	Serine protease HTRA4; Serine protease; PDZ domain containing	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2	0.546
HTRA4	PAPPA2	ENSP00000305919	ENSP00000356634	Serine protease HTRA4; Serine protease; PDZ domain containing	Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the ’163-Ser-\|- Lys-164’ bond. Shows limited proteolysis toward IGFBP-3; Belongs to the peptidase M43B family	0.555
HTRA4	PLEKHA2	ENSP00000305919	ENSP00000482228	Serine protease HTRA4; Serine protease; PDZ domain containing	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.538
HTRA4	PRSS1	ENSP00000305919	ENSP00000308720	Serine protease HTRA4; Serine protease; PDZ domain containing	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.716
HTRA4	PRSS58	ENSP00000305919	ENSP00000446916	Serine protease HTRA4; Serine protease; PDZ domain containing	Serine protease 58; Belongs to the peptidase S1 family	0.724
HTRA4	SMEK1	ENSP00000305919	ENSP00000450864	Serine protease HTRA4; Serine protease; PDZ domain containing	Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on ’Ser-140’ (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair; Belongs to the SMEK family	0.595
HTRA4	TM2D2	ENSP00000305919	ENSP00000416050	Serine protease HTRA4; Serine protease; PDZ domain containing	TM2 domain containing 2	0.609
HTRA4	TM4SF19	ENSP00000305919	ENSP00000273695	Serine protease HTRA4; Serine protease; PDZ domain containing	Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family	0.730
KCNMB3	HTRA4	ENSP00000319370	ENSP00000305919	Calcium-activated potassium channel subunit beta-3; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of [...]	Serine protease HTRA4; Serine protease; PDZ domain containing	0.526
LEPROTL1	HTRA4	ENSP00000428281	ENSP00000305919	Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family	Serine protease HTRA4; Serine protease; PDZ domain containing	0.549
LEPROTL1	SMEK1	ENSP00000428281	ENSP00000450864	Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family	Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on ’Ser-140’ (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair; Belongs to the SMEK family	0.647
LEPROTL1	TM4SF19	ENSP00000428281	ENSP00000273695	Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability; Belongs to the OB-RGRP/VPS55 family	Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family	0.729
LETM2	HTRA4	ENSP00000369291	ENSP00000305919	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2	Serine protease HTRA4; Serine protease; PDZ domain containing	0.546
LETM2	PLEKHA2	ENSP00000369291	ENSP00000482228	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	0.481
LETM2	TM2D2	ENSP00000369291	ENSP00000416050	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2	TM2 domain containing 2	0.600
PAPPA2	HTRA4	ENSP00000356634	ENSP00000305919	Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the ’163-Ser-\|- Lys-164’ bond. Shows limited proteolysis toward IGFBP-3; Belongs to the peptidase M43B family	Serine protease HTRA4; Serine protease; PDZ domain containing	0.555
PLEKHA2	HTRA4	ENSP00000482228	ENSP00000305919	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	Serine protease HTRA4; Serine protease; PDZ domain containing	0.538
PLEKHA2	LETM2	ENSP00000482228	ENSP00000369291	Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity); Pleckstrin homology domain containing	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2	0.481

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