| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AUTS2 | RBFA | ENSP00000344087 | ENSP00000305696 | Autism susceptibility gene 2 protein; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of R [...] | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | 0.525 |
| EIF5B | LTV1 | ENSP00000289371 | ENSP00000356548 | Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes; Belongs to the TRAFAC class translation factor [...] | Protein LTV1 homolog; LTV1 ribosome biogenesis factor | 0.648 |
| EIF5B | PNO1 | ENSP00000289371 | ENSP00000263657 | Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes; Belongs to the TRAFAC class translation factor [...] | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA | 0.549 |
| EIF5B | RBFA | ENSP00000289371 | ENSP00000305696 | Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes; Belongs to the TRAFAC class translation factor [...] | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | 0.545 |
| ERAL1 | RBFA | ENSP00000254928 | ENSP00000305696 | GTPase Era, mitochondrial; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | 0.701 |
| KBTBD6 | RBFA | ENSP00000368799 | ENSP00000305696 | Kelch repeat and BTB domain containing 6 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | 0.518 |
| LTV1 | EIF5B | ENSP00000356548 | ENSP00000289371 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor | Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes; Belongs to the TRAFAC class translation factor [...] | 0.648 |
| LTV1 | PNO1 | ENSP00000356548 | ENSP00000263657 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA | 0.999 |
| LTV1 | RBFA | ENSP00000356548 | ENSP00000305696 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | 0.470 |
| METTL15 | RBFA | ENSP00000384369 | ENSP00000305696 | Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | 0.554 |
| PNO1 | EIF5B | ENSP00000263657 | ENSP00000289371 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA | Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes; Belongs to the TRAFAC class translation factor [...] | 0.549 |
| PNO1 | LTV1 | ENSP00000263657 | ENSP00000356548 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA | Protein LTV1 homolog; LTV1 ribosome biogenesis factor | 0.999 |
| PNO1 | RBFA | ENSP00000263657 | ENSP00000305696 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | 0.511 |
| RBFA | AUTS2 | ENSP00000305696 | ENSP00000344087 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | Autism susceptibility gene 2 protein; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of R [...] | 0.525 |
| RBFA | EIF5B | ENSP00000305696 | ENSP00000289371 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes; Belongs to the TRAFAC class translation factor [...] | 0.545 |
| RBFA | ERAL1 | ENSP00000305696 | ENSP00000254928 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | GTPase Era, mitochondrial; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly | 0.701 |
| RBFA | KBTBD6 | ENSP00000305696 | ENSP00000368799 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | Kelch repeat and BTB domain containing 6 | 0.518 |
| RBFA | LTV1 | ENSP00000305696 | ENSP00000356548 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | Protein LTV1 homolog; LTV1 ribosome biogenesis factor | 0.470 |
| RBFA | METTL15 | ENSP00000305696 | ENSP00000384369 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase | 0.554 |
| RBFA | PNO1 | ENSP00000305696 | ENSP00000263657 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA | 0.511 |
