• Version:
  • 11.0 [archived version]
STRINGSTRING
PTP4A1 PTP4A1 PTP4A2 PTP4A2 FAM58A FAM58A FAM178B FAM178B FAHD2B FAHD2B CNNM3 CNNM3 PTP4A3 PTP4A3 ANKRD39 ANKRD39 CRABP2 CRABP2 FNDC3A FNDC3A HPSE2 HPSE2
"CNNM3" - Metal transporter CNNM3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CNNM3Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family (707 aa)    
Predicted Functional Partners:
PTP4A2
Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (167 aa)
      
 
  0.988
PTP4A3
Protein tyrosine phosphatase type IVA 3; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II; Protein tyrosine phosphatases type IVA (173 aa)
      
 
  0.972
PTP4A1
Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis (173 aa)
      
 
  0.914
HPSE2
Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) (592 aa)
            
  0.757
CRABP2
Cellular retinoic acid-binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors; Fatty acid binding protein family (138 aa)
            
  0.720
FAHD2B
Fumarylacetoacetate hydrolase domain-containing protein 2B; May have hydrolase activity (314 aa)
      
   
  0.659
FAM58A
Cyclin-Q; Activating cyclin for the cyclin-associated kinase CDK10; Belongs to the cyclin family. Cyclin-like FAM58 subfamily (228 aa)
      
   
  0.655
FAM178B
Protein FAM178B; Family with sequence similarity 178 member B (679 aa)
            
  0.640
FNDC3A
Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis; Belongs to the FNDC3 family (1198 aa)
            
  0.627
ANKRD39
Ankyrin repeat domain-containing protein 39; Ankyrin repeat domain containing; Belongs to the ANKRD39 family (183 aa)
      
   
  0.596
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >