ZNF440 protein (human) - STRING database

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ZNF440

Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type (595 aa)

Predicted Functional Partners:

TRIM28

0.925

C19orf44

0.701

MAFIP

0.681

OR6C4

0.669

DUS3L

0.462

SPATA22

0.442

TMPRSS11A

0.406

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C19orf44	ZNF440	ENSP00000221671	ENSP00000305373	Uncharacterized protein C19orf44; Chromosome 19 open reading frame 44	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.701
DUS3L	ZNF440	ENSP00000311977	ENSP00000305373	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.462
MAFIP	OR6C4	ENSP00000483280	ENSP00000377799	MaFF-interacting protein; Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency; Belongs to the tektin family	Olfactory receptor 6C4; Odorant receptor; Olfactory receptors, family 6	0.789
MAFIP	ZNF440	ENSP00000483280	ENSP00000305373	MaFF-interacting protein; Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency; Belongs to the tektin family	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.681
OR6C4	MAFIP	ENSP00000377799	ENSP00000483280	Olfactory receptor 6C4; Odorant receptor; Olfactory receptors, family 6	MaFF-interacting protein; Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency; Belongs to the tektin family	0.789
OR6C4	ZNF440	ENSP00000377799	ENSP00000305373	Olfactory receptor 6C4; Odorant receptor; Olfactory receptors, family 6	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.669
SPATA22	ZNF440	ENSP00000459580	ENSP00000305373	Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.442
TMPRSS11A	ZNF440	ENSP00000334611	ENSP00000305373	Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.406
TRIM28	ZNF440	ENSP00000253024	ENSP00000305373	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.925
ZNF440	C19orf44	ENSP00000305373	ENSP00000221671	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Uncharacterized protein C19orf44; Chromosome 19 open reading frame 44	0.701
ZNF440	DUS3L	ENSP00000305373	ENSP00000311977	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs	0.462
ZNF440	MAFIP	ENSP00000305373	ENSP00000483280	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	MaFF-interacting protein; Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency; Belongs to the tektin family	0.681
ZNF440	OR6C4	ENSP00000305373	ENSP00000377799	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Olfactory receptor 6C4; Odorant receptor; Olfactory receptors, family 6	0.669
ZNF440	SPATA22	ENSP00000305373	ENSP00000459580	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I	0.442
ZNF440	TMPRSS11A	ENSP00000305373	ENSP00000334611	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest	0.406
ZNF440	TRIM28	ENSP00000305373	ENSP00000253024	Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	0.925

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