| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMPER | FSTL5 | ENSP00000297161 | ENSP00000305334 | BMP-binding endothelial regulator protein; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes | Follistatin-related protein 5; EF-hand domain containing | 0.657 |
| CHRDL1 | FSTL3 | ENSP00000361112 | ENSP00000166139 | Chordin-like protein 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior s [...] | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow st [...] | 0.935 |
| CHRDL1 | FSTL5 | ENSP00000361112 | ENSP00000305334 | Chordin-like protein 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior s [...] | Follistatin-related protein 5; EF-hand domain containing | 0.676 |
| CHRDL2 | FSTL3 | ENSP00000263671 | ENSP00000166139 | Chordin-related protein 2 variant III; Chordin like 2 | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow st [...] | 0.444 |
| CHRDL2 | FSTL5 | ENSP00000263671 | ENSP00000305334 | Chordin-related protein 2 variant III; Chordin like 2 | Follistatin-related protein 5; EF-hand domain containing | 0.703 |
| FSTL3 | CHRDL1 | ENSP00000166139 | ENSP00000361112 | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow st [...] | Chordin-like protein 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior s [...] | 0.935 |
| FSTL3 | CHRDL2 | ENSP00000166139 | ENSP00000263671 | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow st [...] | Chordin-related protein 2 variant III; Chordin like 2 | 0.444 |
| FSTL3 | FSTL5 | ENSP00000166139 | ENSP00000305334 | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow st [...] | Follistatin-related protein 5; EF-hand domain containing | 0.647 |
| FSTL5 | BMPER | ENSP00000305334 | ENSP00000297161 | Follistatin-related protein 5; EF-hand domain containing | BMP-binding endothelial regulator protein; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes | 0.657 |
| FSTL5 | CHRDL1 | ENSP00000305334 | ENSP00000361112 | Follistatin-related protein 5; EF-hand domain containing | Chordin-like protein 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior s [...] | 0.676 |
| FSTL5 | CHRDL2 | ENSP00000305334 | ENSP00000263671 | Follistatin-related protein 5; EF-hand domain containing | Chordin-related protein 2 variant III; Chordin like 2 | 0.703 |
| FSTL5 | FSTL3 | ENSP00000305334 | ENSP00000166139 | Follistatin-related protein 5; EF-hand domain containing | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow st [...] | 0.647 |
| FSTL5 | KCTD12 | ENSP00000305334 | ENSP00000366694 | Follistatin-related protein 5; EF-hand domain containing | BTB/POZ domain-containing protein KCTD12; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity) | 0.697 |
| FSTL5 | NKAIN3 | ENSP00000305334 | ENSP00000429073 | Follistatin-related protein 5; EF-hand domain containing | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; Sodium/potassium transporting ATPase interacting 3; Belongs to the NKAIN family | 0.635 |
| FSTL5 | SNX16 | ENSP00000305334 | ENSP00000379621 | Follistatin-related protein 5; EF-hand domain containing | Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm; Belongs to the sorting nexin family | 0.649 |
| FSTL5 | TBL2 | ENSP00000305334 | ENSP00000307260 | Follistatin-related protein 5; EF-hand domain containing | Transducin beta-like protein 2; WD repeat domain containing | 0.644 |
| FSTL5 | ZBBX | ENSP00000305334 | ENSP00000390232 | Follistatin-related protein 5; EF-hand domain containing | Zinc finger B-box domain containing | 0.667 |
| FSTL5 | ZNF366 | ENSP00000305334 | ENSP00000313158 | Follistatin-related protein 5; EF-hand domain containing | Zinc finger protein 366; Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases; Zinc fingers C2H2-type | 0.643 |
| KCTD12 | FSTL5 | ENSP00000366694 | ENSP00000305334 | BTB/POZ domain-containing protein KCTD12; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity) | Follistatin-related protein 5; EF-hand domain containing | 0.697 |
| KCTD12 | SNX16 | ENSP00000366694 | ENSP00000379621 | BTB/POZ domain-containing protein KCTD12; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity) | Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm; Belongs to the sorting nexin family | 0.633 |
