node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DUS3L | ZNF439 | ENSP00000311977 | ENSP00000305077 | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.501 |
HOOK2 | ZNF439 | ENSP00000380785 | ENSP00000305077 | Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.418 |
HTR3E | ZNF439 | ENSP00000406050 | ENSP00000305077 | 5-hydroxytryptamine receptor 3E; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.429 |
MARVELD3 | ZNF439 | ENSP00000299952 | ENSP00000305077 | MARVEL domain containing 3 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.416 |
SPATA22 | ZNF439 | ENSP00000459580 | ENSP00000305077 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.479 |
TMPRSS11A | ZNF439 | ENSP00000334611 | ENSP00000305077 | Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.445 |
TRIM28 | ZNF439 | ENSP00000253024 | ENSP00000305077 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.918 |
USP54 | ZNF439 | ENSP00000345216 | ENSP00000305077 | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.475 |
ZNF439 | DUS3L | ENSP00000305077 | ENSP00000311977 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs | 0.501 |
ZNF439 | HOOK2 | ENSP00000305077 | ENSP00000380785 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones | 0.418 |
ZNF439 | HTR3E | ENSP00000305077 | ENSP00000406050 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 5-hydroxytryptamine receptor 3E; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily | 0.429 |
ZNF439 | MARVELD3 | ENSP00000305077 | ENSP00000299952 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | MARVEL domain containing 3 | 0.416 |
ZNF439 | SPATA22 | ENSP00000305077 | ENSP00000459580 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I | 0.479 |
ZNF439 | TMPRSS11A | ENSP00000305077 | ENSP00000334611 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest | 0.445 |
ZNF439 | TRIM28 | ENSP00000305077 | ENSP00000253024 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.918 |
ZNF439 | USP54 | ENSP00000305077 | ENSP00000345216 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family | 0.475 |