node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BFSP1 | BFSP2 | ENSP00000367104 | ENSP00000304987 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | 0.968 |
BFSP1 | CRYA1 | ENSP00000367104 | ENSP00000482816 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.767 |
BFSP1 | CRYBA1 | ENSP00000367104 | ENSP00000225387 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens | 0.703 |
BFSP1 | CRYBB1 | ENSP00000367104 | ENSP00000215939 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family | 0.750 |
BFSP1 | CRYBB2 | ENSP00000367104 | ENSP00000381273 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family | 0.707 |
BFSP1 | CRYGS | ENSP00000367104 | ENSP00000376287 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family | 0.740 |
BFSP1 | GJA3 | ENSP00000367104 | ENSP00000241125 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily | 0.725 |
BFSP1 | HSF4 | ENSP00000367104 | ENSP00000264009 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | 0.762 |
BFSP1 | HSPB4 | ENSP00000367104 | ENSP00000291554 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.768 |
BFSP1 | MIP | ENSP00000367104 | ENSP00000257979 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.887 |
BFSP2 | BFSP1 | ENSP00000304987 | ENSP00000367104 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family | 0.968 |
BFSP2 | CRYA1 | ENSP00000304987 | ENSP00000482816 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.819 |
BFSP2 | CRYBA1 | ENSP00000304987 | ENSP00000225387 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens | 0.784 |
BFSP2 | CRYBB1 | ENSP00000304987 | ENSP00000215939 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family | 0.798 |
BFSP2 | CRYBB2 | ENSP00000304987 | ENSP00000381273 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family | 0.812 |
BFSP2 | CRYGS | ENSP00000304987 | ENSP00000376287 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family | 0.795 |
BFSP2 | GJA3 | ENSP00000304987 | ENSP00000241125 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily | 0.835 |
BFSP2 | HSF4 | ENSP00000304987 | ENSP00000264009 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | 0.840 |
BFSP2 | HSPB4 | ENSP00000304987 | ENSP00000291554 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.819 |
BFSP2 | MIP | ENSP00000304987 | ENSP00000257979 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.814 |