MPLKIP protein (human) - STRING database

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MPLKIP

M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis (179 aa)

Predicted Functional Partners:

SUGCT

0.906

THY1

0.820

RBM27

0.820

SUGP1

0.818

MRPL53

0.794

SCAMP3

0.789

FAM3B

0.775

SBDS

0.768

DBR1

0.747

CDK13

0.720

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK13	MPLKIP	ENSP00000181839	ENSP00000304553	Cyclin-dependent kinase 13; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at ’Lys-50’ and ’Lys- 51’, thereby increasing HIV-1 mRNA splicing and promoting the pro [...]	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	0.720
DBR1	MPLKIP	ENSP00000260803	ENSP00000304553	Lariat debranching enzyme; Cleaves the 2’-5’ phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis; Belongs to the lariat debranching enzyme family	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	0.747
FAM3B	MPLKIP	ENSP00000350673	ENSP00000304553	Protein FAM3B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner; Belongs to the FAM3 family	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	0.775
FAM3B	SUGCT	ENSP00000350673	ENSP00000338475	Protein FAM3B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner; Belongs to the FAM3 family	Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family	0.536
MPLKIP	CDK13	ENSP00000304553	ENSP00000181839	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	Cyclin-dependent kinase 13; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at ’Lys-50’ and ’Lys- 51’, thereby increasing HIV-1 mRNA splicing and promoting the pro [...]	0.720
MPLKIP	DBR1	ENSP00000304553	ENSP00000260803	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	Lariat debranching enzyme; Cleaves the 2’-5’ phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis; Belongs to the lariat debranching enzyme family	0.747
MPLKIP	FAM3B	ENSP00000304553	ENSP00000350673	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	Protein FAM3B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner; Belongs to the FAM3 family	0.775
MPLKIP	MRPL53	ENSP00000304553	ENSP00000258105	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	Mitochondrial ribosomal protein L53	0.794
MPLKIP	RBM27	ENSP00000304553	ENSP00000265271	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	RNA-binding protein 27; RNA binding motif containing	0.820
MPLKIP	SBDS	ENSP00000304553	ENSP00000246868	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell prolife [...]	0.768
MPLKIP	SCAMP3	ENSP00000304553	ENSP00000307275	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	Secretory carrier-associated membrane protein 3; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface; Belongs to the SCAMP family	0.789
MPLKIP	SUGCT	ENSP00000304553	ENSP00000338475	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family	0.906
MPLKIP	SUGP1	ENSP00000304553	ENSP00000247001	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	SURP and G-patch domain-containing protein 1; Plays a role in pre-mRNA splicing; G-patch domain containing	0.818
MPLKIP	THY1	ENSP00000304553	ENSP00000284240	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules	0.820
MRPL53	MPLKIP	ENSP00000258105	ENSP00000304553	Mitochondrial ribosomal protein L53	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	0.794
MRPL53	RBM27	ENSP00000258105	ENSP00000265271	Mitochondrial ribosomal protein L53	RNA-binding protein 27; RNA binding motif containing	0.815
MRPL53	SBDS	ENSP00000258105	ENSP00000246868	Mitochondrial ribosomal protein L53	Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell prolife [...]	0.820
MRPL53	SUGP1	ENSP00000258105	ENSP00000247001	Mitochondrial ribosomal protein L53	SURP and G-patch domain-containing protein 1; Plays a role in pre-mRNA splicing; G-patch domain containing	0.818
MRPL53	THY1	ENSP00000258105	ENSP00000284240	Mitochondrial ribosomal protein L53	Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules	0.818
RBM27	MPLKIP	ENSP00000265271	ENSP00000304553	RNA-binding protein 27; RNA binding motif containing	M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis	0.820

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