| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASPM | SNX7 | ENSP00000356379 | ENSP00000304429 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.750 |
| BLOC1S2 | SNX7 | ENSP00000359398 | ENSP00000304429 | Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in l [...] | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.866 |
| FNDC7 | FRMD8 | ENSP00000359034 | ENSP00000319726 | Fibronectin type III domain containing 7 | FERM domain containing 8 | 0.730 |
| FNDC7 | SNX7 | ENSP00000359034 | ENSP00000304429 | Fibronectin type III domain containing 7 | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.641 |
| FRMD8 | FNDC7 | ENSP00000319726 | ENSP00000359034 | FERM domain containing 8 | Fibronectin type III domain containing 7 | 0.730 |
| FRMD8 | SNX7 | ENSP00000319726 | ENSP00000304429 | FERM domain containing 8 | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.587 |
| LPPR5 | SNX7 | ENSP00000263177 | ENSP00000304429 | Phospholipid phosphatase-related protein type 5; Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory- mediated axonal retraction; Belongs to the PA-phosphatase related phosphoesterase family | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.665 |
| SNX32 | SNX6 | ENSP00000310620 | ENSP00000355217 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | 0.860 |
| SNX32 | SNX7 | ENSP00000310620 | ENSP00000304429 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.722 |
| SNX32 | VPS26B | ENSP00000310620 | ENSP00000281187 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.686 |
| SNX32 | VPS29 | ENSP00000310620 | ENSP00000480853 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo [...] | 0.713 |
| SNX32 | VPS35 | ENSP00000310620 | ENSP00000299138 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | 0.655 |
| SNX6 | SNX32 | ENSP00000355217 | ENSP00000310620 | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | 0.860 |
| SNX6 | SNX7 | ENSP00000355217 | ENSP00000304429 | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | 0.779 |
| SNX6 | VPS26B | ENSP00000355217 | ENSP00000281187 | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.928 |
| SNX6 | VPS29 | ENSP00000355217 | ENSP00000480853 | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo [...] | 0.990 |
| SNX6 | VPS35 | ENSP00000355217 | ENSP00000299138 | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | 0.973 |
| SNX7 | ASPM | ENSP00000304429 | ENSP00000356379 | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | 0.750 |
| SNX7 | BLOC1S2 | ENSP00000304429 | ENSP00000359398 | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in l [...] | 0.866 |
| SNX7 | FNDC7 | ENSP00000304429 | ENSP00000359034 | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family | Fibronectin type III domain containing 7 | 0.641 |
