| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1D | TM4SF1 | ENSP00000348107 | ENSP00000304277 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3’-5’ end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity) | Transmembrane 4 L six family member 1 | 0.714 |
| CD37 | CD53 | ENSP00000325708 | ENSP00000271324 | Leukocyte antigen CD37; CD37 molecule | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity); CD molecules | 0.509 |
| CD37 | TM4SF1 | ENSP00000325708 | ENSP00000304277 | Leukocyte antigen CD37; CD37 molecule | Transmembrane 4 L six family member 1 | 0.628 |
| CD37 | TSPAN31 | ENSP00000325708 | ENSP00000257910 | Leukocyte antigen CD37; CD37 molecule | Tetraspanin-31; Tetraspanin 31; Tetraspanins | 0.535 |
| CD53 | CD37 | ENSP00000271324 | ENSP00000325708 | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity); CD molecules | Leukocyte antigen CD37; CD37 molecule | 0.509 |
| CD53 | TM4SF1 | ENSP00000271324 | ENSP00000304277 | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity); CD molecules | Transmembrane 4 L six family member 1 | 0.640 |
| CD53 | TSPAN31 | ENSP00000271324 | ENSP00000257910 | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity); CD molecules | Tetraspanin-31; Tetraspanin 31; Tetraspanins | 0.541 |
| CD63 | TM4SF1 | ENSP00000447730 | ENSP00000304277 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | Transmembrane 4 L six family member 1 | 0.715 |
| CD63 | TSPAN31 | ENSP00000447730 | ENSP00000257910 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | Tetraspanin-31; Tetraspanin 31; Tetraspanins | 0.494 |
| DDR1 | TM4SF1 | ENSP00000427552 | ENSP00000304277 | Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required fo [...] | Transmembrane 4 L six family member 1 | 0.693 |
| MYO10 | TM4SF1 | ENSP00000421280 | ENSP00000304277 | Unconventional myosin-X; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons i [...] | Transmembrane 4 L six family member 1 | 0.629 |
| RHBG | TM4SF1 | ENSP00000441197 | ENSP00000304277 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter; Solute carriers | Transmembrane 4 L six family member 1 | 0.627 |
| TM4SF1 | C1D | ENSP00000304277 | ENSP00000348107 | Transmembrane 4 L six family member 1 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3’-5’ end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity) | 0.714 |
| TM4SF1 | CD37 | ENSP00000304277 | ENSP00000325708 | Transmembrane 4 L six family member 1 | Leukocyte antigen CD37; CD37 molecule | 0.628 |
| TM4SF1 | CD53 | ENSP00000304277 | ENSP00000271324 | Transmembrane 4 L six family member 1 | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity); CD molecules | 0.640 |
| TM4SF1 | CD63 | ENSP00000304277 | ENSP00000447730 | Transmembrane 4 L six family member 1 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] | 0.715 |
| TM4SF1 | DDR1 | ENSP00000304277 | ENSP00000427552 | Transmembrane 4 L six family member 1 | Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required fo [...] | 0.693 |
| TM4SF1 | MYO10 | ENSP00000304277 | ENSP00000421280 | Transmembrane 4 L six family member 1 | Unconventional myosin-X; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons i [...] | 0.629 |
| TM4SF1 | RHBG | ENSP00000304277 | ENSP00000441197 | Transmembrane 4 L six family member 1 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter; Solute carriers | 0.627 |
| TM4SF1 | TSPAN1 | ENSP00000304277 | ENSP00000361072 | Transmembrane 4 L six family member 1 | Tetraspanin-1; Tetraspanin 1; Tetraspanins | 0.670 |
