node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDK5 | CDK5R2 | ENSP00000419782 | ENSP00000304250 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several ne [...] | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.993 |
CDK5 | NDEL1 | ENSP00000419782 | ENSP00000333982 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several ne [...] | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | 0.994 |
CDK5R2 | CDK5 | ENSP00000304250 | ENSP00000419782 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several ne [...] | 0.993 |
CDK5R2 | CHGB | ENSP00000304250 | ENSP00000368244 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | 0.625 |
CDK5R2 | DNAJC5B | ENSP00000304250 | ENSP00000276570 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | DnaJ heat shock protein family member C5 beta | 0.626 |
CDK5R2 | NDEL1 | ENSP00000304250 | ENSP00000333982 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | 0.923 |
CDK5R2 | NEUROD1 | ENSP00000304250 | ENSP00000295108 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Neurogenic differentiation factor 1; Acts as a transcriptional activator- mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5’-CANNTG-3’. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] | 0.626 |
CDK5R2 | NMNAT2 | ENSP00000304250 | ENSP00000287713 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphory [...] | 0.635 |
CDK5R2 | RUFY4 | ENSP00000304250 | ENSP00000363270 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | RUN and FYVE domain containing 4; Zinc fingers FYVE-type | 0.723 |
CDK5R2 | SCRT1 | ENSP00000304250 | ENSP00000455711 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation; SNAG transcriptional repressors | 0.597 |
CDK5R2 | SLC12A5 | ENSP00000304250 | ENSP00000387694 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Solute carrier family 12 member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation; Solute carriers | 0.596 |
CDK5R2 | ZNF142 | ENSP00000304250 | ENSP00000398798 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | Zinc finger protein 142; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.721 |
CHGB | CDK5R2 | ENSP00000368244 | ENSP00000304250 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.625 |
DNAJC5B | CDK5R2 | ENSP00000276570 | ENSP00000304250 | DnaJ heat shock protein family member C5 beta | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.626 |
NDEL1 | CDK5 | ENSP00000333982 | ENSP00000419782 | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several ne [...] | 0.994 |
NDEL1 | CDK5R2 | ENSP00000333982 | ENSP00000304250 | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.923 |
NEUROD1 | CDK5R2 | ENSP00000295108 | ENSP00000304250 | Neurogenic differentiation factor 1; Acts as a transcriptional activator- mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5’-CANNTG-3’. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.626 |
NEUROD1 | SCRT1 | ENSP00000295108 | ENSP00000455711 | Neurogenic differentiation factor 1; Acts as a transcriptional activator- mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5’-CANNTG-3’. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] | Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation; SNAG transcriptional repressors | 0.428 |
NMNAT2 | CDK5R2 | ENSP00000287713 | ENSP00000304250 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphory [...] | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.635 |
RUFY4 | CDK5R2 | ENSP00000363270 | ENSP00000304250 | RUN and FYVE domain containing 4; Zinc fingers FYVE-type | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII | 0.723 |