| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BOLA3 | EXD3 | ENSP00000331369 | ENSP00000340474 | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | Exonuclease mut-7 homolog; Possesses 3’-5’ exoribonuclease activity. Required for 3’-end trimming of AGO1-bound miRNAs (By similarity) | 0.445 |
| BOLA3 | ZFYVE28 | ENSP00000331369 | ENSP00000290974 | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | 0.571 |
| BOLA3 | ZNF561 | ENSP00000331369 | ENSP00000303915 | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.572 |
| EXD3 | BOLA3 | ENSP00000340474 | ENSP00000331369 | Exonuclease mut-7 homolog; Possesses 3’-5’ exoribonuclease activity. Required for 3’-end trimming of AGO1-bound miRNAs (By similarity) | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | 0.445 |
| EXD3 | ZFYVE28 | ENSP00000340474 | ENSP00000290974 | Exonuclease mut-7 homolog; Possesses 3’-5’ exoribonuclease activity. Required for 3’-end trimming of AGO1-bound miRNAs (By similarity) | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | 0.543 |
| EXD3 | ZNF561 | ENSP00000340474 | ENSP00000303915 | Exonuclease mut-7 homolog; Possesses 3’-5’ exoribonuclease activity. Required for 3’-end trimming of AGO1-bound miRNAs (By similarity) | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.561 |
| ITPKB | ZNF561 | ENSP00000411152 | ENSP00000303915 | Inositol-trisphosphate 3-kinase B | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.497 |
| MN1 | ZNF561 | ENSP00000304956 | ENSP00000303915 | Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable) | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.420 |
| SLITRK1 | ZNF561 | ENSP00000366288 | ENSP00000303915 | SLIT and NTRK-like protein 1; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.429 |
| TRIM28 | ZNF561 | ENSP00000253024 | ENSP00000303915 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
| TRIM28 | ZNF562 | ENSP00000253024 | ENSP00000410734 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
| ZFYVE28 | BOLA3 | ENSP00000290974 | ENSP00000331369 | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | 0.571 |
| ZFYVE28 | EXD3 | ENSP00000290974 | ENSP00000340474 | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | Exonuclease mut-7 homolog; Possesses 3’-5’ exoribonuclease activity. Required for 3’-end trimming of AGO1-bound miRNAs (By similarity) | 0.543 |
| ZFYVE28 | ZNF561 | ENSP00000290974 | ENSP00000303915 | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.589 |
| ZNF561 | BOLA3 | ENSP00000303915 | ENSP00000331369 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | 0.572 |
| ZNF561 | EXD3 | ENSP00000303915 | ENSP00000340474 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Exonuclease mut-7 homolog; Possesses 3’-5’ exoribonuclease activity. Required for 3’-end trimming of AGO1-bound miRNAs (By similarity) | 0.561 |
| ZNF561 | ITPKB | ENSP00000303915 | ENSP00000411152 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Inositol-trisphosphate 3-kinase B | 0.497 |
| ZNF561 | MN1 | ENSP00000303915 | ENSP00000304956 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable) | 0.420 |
| ZNF561 | SLITRK1 | ENSP00000303915 | ENSP00000366288 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | SLIT and NTRK-like protein 1; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth | 0.429 |
| ZNF561 | TRIM28 | ENSP00000303915 | ENSP00000253024 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.903 |
