• Version:
  • 11.0 [archived version]
STRINGSTRING
MOG MOG TCF19 TCF19 TRIM28 TRIM28 POU5F1 POU5F1 CCHCR1 CCHCR1 ETF1 ETF1 RNF39 RNF39 CDSN CDSN ZNF57 ZNF57 RMND5A RMND5A OR5D14 OR5D14
"ZNF57" - Zinc finger protein 57 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF57Zinc finger protein 57; May be involved in transcriptional regulation; Zinc fingers C2H2-type (555 aa)    
Predicted Functional Partners:
RNF39
RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance; Ring finger proteins (420 aa)
     
 
  0.732
TCF19
Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger proteins (345 aa)
           
  0.721
CCHCR1
Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation (871 aa)
       
 
  0.719
CDSN
Corneodesmosin; Important for the epidermal barrier integrity (529 aa)
           
  0.676
MOG
Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication; Belongs to the immunoglobulin superfamily. BTN/MOG family (252 aa)
           
  0.639
OR5D14
Olfactory receptor 5D14; Odorant receptor; Olfactory receptors, family 5 (314 aa)
           
  0.631
ETF1
Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (437 aa)
       
 
  0.604
POU5F1
POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5’-ATTTGCAT-3’). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (360 aa)
       
 
  0.553
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
 
  0.464
RMND5A
Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex (391 aa)
     
   
  0.452
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]