C5orf34 protein (human) - STRING database

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C5orf34

Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34 (638 aa)

Predicted Functional Partners:

ZNF391

0.615

CCPG1

0.568

DNAJC21

0.567

LRRC66

0.559

CCDC124

0.558

PPP1R16B

0.511

LRRC36

0.511

TMEM178A

0.510

ZBTB11

0.491

DCUN1D4

0.442

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C5orf34	CCDC124	ENSP00000303490	ENSP00000471455	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	0.558
C5orf34	CCPG1	ENSP00000303490	ENSP00000403400	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	Cell cycle progression protein 1; Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation; Belongs to the CCPG1 family	0.568
C5orf34	DCUN1D4	ENSP00000303490	ENSP00000389900	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4	0.442
C5orf34	DNAJC21	ENSP00000303490	ENSP00000371451	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins	0.567
C5orf34	LRRC36	ENSP00000303490	ENSP00000329943	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	Leucine-rich repeat-containing protein 36; Leucine rich repeat containing 36	0.511
C5orf34	LRRC66	ENSP00000303490	ENSP00000341944	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66	0.559
C5orf34	PPP1R16B	ENSP00000303490	ENSP00000299824	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	Protein phosphatase 1 regulatory inhibitor subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)- induced vascular leakage (By similarity). Involved in the regulation of endothelial ce [...]	0.511
C5orf34	TMEM178A	ENSP00000303490	ENSP00000281961	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1; Belongs to the TMEM178 family	0.510
C5orf34	ZBTB11	ENSP00000303490	ENSP00000326200	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation; BTB domain containing	0.491
C5orf34	ZNF391	ENSP00000303490	ENSP00000244576	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	Zinc finger protein 391; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.615
CCDC124	C5orf34	ENSP00000471455	ENSP00000303490	Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	0.558
CCPG1	C5orf34	ENSP00000403400	ENSP00000303490	Cell cycle progression protein 1; Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation; Belongs to the CCPG1 family	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	0.568
CCPG1	DNAJC21	ENSP00000403400	ENSP00000371451	Cell cycle progression protein 1; Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation; Belongs to the CCPG1 family	DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins	0.464
DCUN1D4	C5orf34	ENSP00000389900	ENSP00000303490	DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	0.442
DCUN1D4	LRRC66	ENSP00000389900	ENSP00000341944	DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4	Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66	0.473
DNAJC21	C5orf34	ENSP00000371451	ENSP00000303490	DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	0.567
DNAJC21	CCPG1	ENSP00000371451	ENSP00000403400	DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins	Cell cycle progression protein 1; Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation; Belongs to the CCPG1 family	0.464
DNAJC21	PPP1R16B	ENSP00000371451	ENSP00000299824	DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins	Protein phosphatase 1 regulatory inhibitor subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)- induced vascular leakage (By similarity). Involved in the regulation of endothelial ce [...]	0.409
LRRC36	C5orf34	ENSP00000329943	ENSP00000303490	Leucine-rich repeat-containing protein 36; Leucine rich repeat containing 36	Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34	0.511
LRRC36	TMEM178A	ENSP00000329943	ENSP00000281961	Leucine-rich repeat-containing protein 36; Leucine rich repeat containing 36	Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1; Belongs to the TMEM178 family	0.486

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