node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACACB | ACAT1 | ENSP00000341044 | ENSP00000265838 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.918 |
ACACB | ACAT2 | ENSP00000341044 | ENSP00000356015 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 0.913 |
ACACB | ACOT12 | ENSP00000341044 | ENSP00000303246 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | Acyl-coenzyme A thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA; Acyl-CoA thioesterases | 0.907 |
ACACB | ACSS1 | ENSP00000341044 | ENSP00000316924 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.942 |
ACACB | ACSS2 | ENSP00000341044 | ENSP00000253382 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | Acetyl-coenzyme A synthetase, cytoplasmic; Activates acetate so that it can be used for lipid synthesis or for energy generation; Acyl-CoA synthetase family | 0.959 |
ACACB | DLAT | ENSP00000341044 | ENSP00000280346 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | Dihydrolipoamide S-acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.922 |
ACAT1 | ACACB | ENSP00000265838 | ENSP00000341044 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | 0.918 |
ACAT1 | ACAT2 | ENSP00000265838 | ENSP00000356015 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 0.947 |
ACAT1 | ACOT12 | ENSP00000265838 | ENSP00000303246 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Acyl-coenzyme A thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA; Acyl-CoA thioesterases | 0.913 |
ACAT1 | ACSS1 | ENSP00000265838 | ENSP00000316924 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.922 |
ACAT1 | ACSS2 | ENSP00000265838 | ENSP00000253382 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Acetyl-coenzyme A synthetase, cytoplasmic; Activates acetate so that it can be used for lipid synthesis or for energy generation; Acyl-CoA synthetase family | 0.939 |
ACAT1 | DLAT | ENSP00000265838 | ENSP00000280346 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Dihydrolipoamide S-acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.955 |
ACAT2 | ACACB | ENSP00000356015 | ENSP00000341044 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | 0.913 |
ACAT2 | ACAT1 | ENSP00000356015 | ENSP00000265838 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.947 |
ACAT2 | ACOT12 | ENSP00000356015 | ENSP00000303246 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Acyl-coenzyme A thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA; Acyl-CoA thioesterases | 0.914 |
ACAT2 | ACSS1 | ENSP00000356015 | ENSP00000316924 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.921 |
ACAT2 | ACSS2 | ENSP00000356015 | ENSP00000253382 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Acetyl-coenzyme A synthetase, cytoplasmic; Activates acetate so that it can be used for lipid synthesis or for energy generation; Acyl-CoA synthetase family | 0.931 |
ACAT2 | DLAT | ENSP00000356015 | ENSP00000280346 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Dihydrolipoamide S-acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle | 0.929 |
ACOT12 | ACACB | ENSP00000303246 | ENSP00000341044 | Acyl-coenzyme A thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA; Acyl-CoA thioesterases | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | 0.907 |
ACOT12 | ACAT1 | ENSP00000303246 | ENSP00000265838 | Acyl-coenzyme A thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA; Acyl-CoA thioesterases | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.913 |