| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCY5 | GPR15 | ENSP00000419361 | ENSP00000284311 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | 0.900 |
| ADCY5 | GPR150 | ENSP00000419361 | ENSP00000369344 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | Probable G-protein coupled receptor 150; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.904 |
| ADCY5 | GPR176 | ENSP00000419361 | ENSP00000453076 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production | 0.906 |
| ADCY5 | GPR20 | ENSP00000419361 | ENSP00000366970 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP; G protein-coupled receptors, Class A orphans | 0.900 |
| ADCY5 | GPR25 | ENSP00000419361 | ENSP00000301917 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.904 |
| ADCY5 | GPR27 | ENSP00000419361 | ENSP00000303149 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G- protein coupled receptor; G protein-coupled receptors, Class A orphans | 0.925 |
| ADCY5 | GPR45 | ENSP00000419361 | ENSP00000258456 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans | 0.906 |
| ADCY5 | GPR84 | ENSP00000419361 | ENSP00000450310 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10-0), undecanoic acid (C11-0) and lauric acid (C12-0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system | 0.904 |
| ADCY5 | PTGIR | ENSP00000419361 | ENSP00000291294 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase | 0.927 |
| ADCY5 | RXFP1 | ENSP00000419361 | ENSP00000405841 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | 0.921 |
| GPR15 | ADCY5 | ENSP00000284311 | ENSP00000419361 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Adenylate cyclases | 0.900 |
| GPR15 | GPR150 | ENSP00000284311 | ENSP00000369344 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | Probable G-protein coupled receptor 150; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.940 |
| GPR15 | GPR176 | ENSP00000284311 | ENSP00000453076 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production | 0.921 |
| GPR15 | GPR20 | ENSP00000284311 | ENSP00000366970 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP; G protein-coupled receptors, Class A orphans | 0.920 |
| GPR15 | GPR25 | ENSP00000284311 | ENSP00000301917 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.921 |
| GPR15 | GPR27 | ENSP00000284311 | ENSP00000303149 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G- protein coupled receptor; G protein-coupled receptors, Class A orphans | 0.934 |
| GPR15 | GPR45 | ENSP00000284311 | ENSP00000258456 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans | 0.912 |
| GPR15 | GPR84 | ENSP00000284311 | ENSP00000450310 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10-0), undecanoic acid (C11-0) and lauric acid (C12-0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system | 0.918 |
| GPR15 | PTGIR | ENSP00000284311 | ENSP00000291294 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase | 0.900 |
| GPR15 | RXFP1 | ENSP00000284311 | ENSP00000405841 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | 0.903 |
