| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EPS8L3 | IGSF23 | ENSP00000358820 | ENSP00000385592 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | 0.633 |
| EPS8L3 | REG4 | ENSP00000358820 | ENSP00000346158 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | 0.654 |
| EPS8L3 | TM4SF20 | ENSP00000358820 | ENSP00000303028 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.516 |
| GPA33 | PLLP | ENSP00000356842 | ENSP00000219207 | Cell surface A33 antigen; May play a role in cell-cell recognition and signaling; IgCAM CXADR-related subfamily | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family | 0.500 |
| GPA33 | TM4SF20 | ENSP00000356842 | ENSP00000303028 | Cell surface A33 antigen; May play a role in cell-cell recognition and signaling; IgCAM CXADR-related subfamily | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.613 |
| IGSF23 | EPS8L3 | ENSP00000385592 | ENSP00000358820 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | 0.633 |
| IGSF23 | REG4 | ENSP00000385592 | ENSP00000346158 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | 0.716 |
| IGSF23 | TM4SF20 | ENSP00000385592 | ENSP00000303028 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.609 |
| PLLP | GPA33 | ENSP00000219207 | ENSP00000356842 | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family | Cell surface A33 antigen; May play a role in cell-cell recognition and signaling; IgCAM CXADR-related subfamily | 0.500 |
| PLLP | TM4SF20 | ENSP00000219207 | ENSP00000303028 | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.545 |
| REG4 | EPS8L3 | ENSP00000346158 | ENSP00000358820 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | 0.654 |
| REG4 | IGSF23 | ENSP00000346158 | ENSP00000385592 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | 0.716 |
| REG4 | TM4SF20 | ENSP00000346158 | ENSP00000303028 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.584 |
| TEX261 | TM4SF20 | ENSP00000272438 | ENSP00000303028 | Protein TEX261; Testis expressed 261 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.549 |
| TEX261 | TTC16 | ENSP00000272438 | ENSP00000362386 | Protein TEX261; Testis expressed 261 | Tetratricopeptide repeat domain containing | 0.715 |
| TM4SF18 | TM4SF20 | ENSP00000296059 | ENSP00000303028 | Transmembrane 4 L six family member 18 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.675 |
| TM4SF19 | TM4SF20 | ENSP00000273695 | ENSP00000303028 | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | 0.591 |
| TM4SF20 | EPS8L3 | ENSP00000303028 | ENSP00000358820 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | 0.516 |
| TM4SF20 | GPA33 | ENSP00000303028 | ENSP00000356842 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | Cell surface A33 antigen; May play a role in cell-cell recognition and signaling; IgCAM CXADR-related subfamily | 0.613 |
| TM4SF20 | IGSF23 | ENSP00000303028 | ENSP00000385592 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...] | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | 0.609 |
