| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PDCD7 | RNPC3 | ENSP00000204549 | ENSP00000432886 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | 0.935 |
| PDCD7 | SF3B1 | ENSP00000204549 | ENSP00000335321 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.900 |
| PDCD7 | SF3B2 | ENSP00000204549 | ENSP00000318861 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.900 |
| PDCD7 | SNRNP35 | ENSP00000204549 | ENSP00000403310 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Small nuclear ribonucleoprotein U11/U12 subunit 35; RNA binding motif containing | 0.993 |
| PDCD7 | SNRNP48 | ENSP00000204549 | ENSP00000339834 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5’ splice site recognition; U11/U12 di-snRNP | 0.900 |
| PDCD7 | SRSF1 | ENSP00000204549 | ENSP00000258962 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | 0.914 |
| PDCD7 | ZCRB1 | ENSP00000204549 | ENSP00000266529 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Zinc finger CCHC-type and RNA binding motif containing 1 | 0.957 |
| PDCD7 | ZMAT5 | ENSP00000204549 | ENSP00000344241 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | Zinc finger matrin-type 5; U11/U12 di-snRNP | 0.985 |
| PDCD7 | ZRSR2 | ENSP00000204549 | ENSP00000303015 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3’-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing | 0.979 |
| RNPC3 | PDCD7 | ENSP00000432886 | ENSP00000204549 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | 0.935 |
| RNPC3 | SF3B1 | ENSP00000432886 | ENSP00000335321 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.978 |
| RNPC3 | SF3B2 | ENSP00000432886 | ENSP00000318861 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | 0.970 |
| RNPC3 | SNRNP35 | ENSP00000432886 | ENSP00000403310 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Small nuclear ribonucleoprotein U11/U12 subunit 35; RNA binding motif containing | 0.988 |
| RNPC3 | SNRNP48 | ENSP00000432886 | ENSP00000339834 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5’ splice site recognition; U11/U12 di-snRNP | 0.942 |
| RNPC3 | SRSF1 | ENSP00000432886 | ENSP00000258962 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | 0.929 |
| RNPC3 | ZCRB1 | ENSP00000432886 | ENSP00000266529 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Zinc finger CCHC-type and RNA binding motif containing 1 | 0.975 |
| RNPC3 | ZMAT5 | ENSP00000432886 | ENSP00000344241 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | Zinc finger matrin-type 5; U11/U12 di-snRNP | 0.992 |
| RNPC3 | ZRSR2 | ENSP00000432886 | ENSP00000303015 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3’-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing | 0.993 |
| SF3B1 | PDCD7 | ENSP00000335321 | ENSP00000204549 | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP | 0.900 |
| SF3B1 | RNPC3 | ENSP00000335321 | ENSP00000432886 | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron; Armadillo-like helical d [...] | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA; RNA binding motif containing | 0.978 |
