node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL17D | IL17RB | ENSP00000302924 | ENSP00000288167 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells; Interleukin receptors | 0.765 |
IL17D | IL17RC | ENSP00000302924 | ENSP00000295981 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Interleukin-17 receptor C; Isoform 8- Receptor for both IL17A and IL17F; Interleukin receptors | 0.752 |
IL17D | IL17RE | ENSP00000302924 | ENSP00000373325 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Interleukin-17 receptor E; Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors | 0.766 |
IL17D | IL20RA | ENSP00000302924 | ENSP00000314976 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26; Interleukin receptors | 0.780 |
IL17D | IL23R | ENSP00000302924 | ENSP00000321345 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Interleukin-23 receptor; Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis; Belongs to the type I cytokine receptor family. Type 2 subfamily | 0.760 |
IL17D | IL25 | ENSP00000302924 | ENSP00000328111 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Interleukin-25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses; Belongs to the IL-17 family | 0.862 |
IL17D | IL27RA | ENSP00000302924 | ENSP00000263379 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Interleukin-27 receptor subunit alpha; Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms; Fibronectin type III domain containing | 0.820 |
IL17D | JAK1 | ENSP00000302924 | ENSP00000343204 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor; FERM domain containing | 0.821 |
IL17D | JAK2 | ENSP00000302924 | ENSP00000371067 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, [...] | 0.813 |
IL17D | TYK2 | ENSP00000302924 | ENSP00000431885 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | Non-receptor tyrosine-protein kinase TYK2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain; FERM domain containing | 0.821 |
IL17RB | IL17D | ENSP00000288167 | ENSP00000302924 | Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells; Interleukin receptors | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | 0.765 |
IL17RB | IL17RC | ENSP00000288167 | ENSP00000295981 | Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells; Interleukin receptors | Interleukin-17 receptor C; Isoform 8- Receptor for both IL17A and IL17F; Interleukin receptors | 0.759 |
IL17RB | IL17RE | ENSP00000288167 | ENSP00000373325 | Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells; Interleukin receptors | Interleukin-17 receptor E; Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors | 0.803 |
IL17RB | IL23R | ENSP00000288167 | ENSP00000321345 | Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells; Interleukin receptors | Interleukin-23 receptor; Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis; Belongs to the type I cytokine receptor family. Type 2 subfamily | 0.411 |
IL17RB | IL25 | ENSP00000288167 | ENSP00000328111 | Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells; Interleukin receptors | Interleukin-25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses; Belongs to the IL-17 family | 0.992 |
IL17RC | IL17D | ENSP00000295981 | ENSP00000302924 | Interleukin-17 receptor C; Isoform 8- Receptor for both IL17A and IL17F; Interleukin receptors | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins | 0.752 |
IL17RC | IL17RB | ENSP00000295981 | ENSP00000288167 | Interleukin-17 receptor C; Isoform 8- Receptor for both IL17A and IL17F; Interleukin receptors | Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells; Interleukin receptors | 0.759 |
IL17RC | IL23R | ENSP00000295981 | ENSP00000321345 | Interleukin-17 receptor C; Isoform 8- Receptor for both IL17A and IL17F; Interleukin receptors | Interleukin-23 receptor; Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis; Belongs to the type I cytokine receptor family. Type 2 subfamily | 0.473 |
IL17RC | IL25 | ENSP00000295981 | ENSP00000328111 | Interleukin-17 receptor C; Isoform 8- Receptor for both IL17A and IL17F; Interleukin receptors | Interleukin-25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses; Belongs to the IL-17 family | 0.735 |
IL17RC | IL27RA | ENSP00000295981 | ENSP00000263379 | Interleukin-17 receptor C; Isoform 8- Receptor for both IL17A and IL17F; Interleukin receptors | Interleukin-27 receptor subunit alpha; Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms; Fibronectin type III domain containing | 0.407 |