node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJC12 | DNAJC15 | ENSP00000225171 | ENSP00000368523 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | 0.575 |
DNAJC12 | DNAJC18 | ENSP00000225171 | ENSP00000302843 | DnaJ heat shock protein family member C12 | DnaJ heat shock protein family member C18 | 0.652 |
DNAJC12 | DNAJC24 | ENSP00000225171 | ENSP00000417548 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family | 0.629 |
DNAJC12 | DNAJC28 | ENSP00000225171 | ENSP00000479716 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins | 0.587 |
DNAJC12 | DNAJC8 | ENSP00000225171 | ENSP00000263697 | DnaJ heat shock protein family member C12 | DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins | 0.740 |
DNAJC12 | HSPH1 | ENSP00000225171 | ENSP00000318687 | DnaJ heat shock protein family member C12 | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity); Heat shock 70kDa proteins | 0.505 |
DNAJC15 | DNAJC12 | ENSP00000368523 | ENSP00000225171 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | DnaJ heat shock protein family member C12 | 0.575 |
DNAJC15 | DNAJC18 | ENSP00000368523 | ENSP00000302843 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | DnaJ heat shock protein family member C18 | 0.629 |
DNAJC15 | DNAJC24 | ENSP00000368523 | ENSP00000417548 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family | 0.610 |
DNAJC15 | DNAJC28 | ENSP00000368523 | ENSP00000479716 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins | 0.567 |
DNAJC15 | DNAJC8 | ENSP00000368523 | ENSP00000263697 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins | 0.613 |
DNAJC15 | HSPA9 | ENSP00000368523 | ENSP00000297185 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity); Belongs to the heat shock protein 70 family | 0.711 |
DNAJC18 | DNAJC12 | ENSP00000302843 | ENSP00000225171 | DnaJ heat shock protein family member C18 | DnaJ heat shock protein family member C12 | 0.652 |
DNAJC18 | DNAJC15 | ENSP00000302843 | ENSP00000368523 | DnaJ heat shock protein family member C18 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | 0.629 |
DNAJC18 | DNAJC24 | ENSP00000302843 | ENSP00000417548 | DnaJ heat shock protein family member C18 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family | 0.676 |
DNAJC18 | DNAJC28 | ENSP00000302843 | ENSP00000479716 | DnaJ heat shock protein family member C18 | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins | 0.675 |
DNAJC18 | DNAJC8 | ENSP00000302843 | ENSP00000263697 | DnaJ heat shock protein family member C18 | DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins | 0.806 |
DNAJC18 | HSPA8 | ENSP00000302843 | ENSP00000432083 | DnaJ heat shock protein family member C18 | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.658 |
DNAJC18 | HSPA9 | ENSP00000302843 | ENSP00000297185 | DnaJ heat shock protein family member C18 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity); Belongs to the heat shock protein 70 family | 0.693 |
DNAJC18 | HSPB9 | ENSP00000302843 | ENSP00000458018 | DnaJ heat shock protein family member C18 | Heat shock protein family B member 9 | 0.757 |