| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTR1A | ACTR1B | ENSP00000358921 | ENSP00000289228 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.985 |
| ACTR1A | OTP | ENSP00000358921 | ENSP00000302814 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | 0.638 |
| ACTR1B | ACTR1A | ENSP00000289228 | ENSP00000358921 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.985 |
| ACTR1B | OTP | ENSP00000289228 | ENSP00000302814 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | 0.650 |
| FEZF2 | FOXB1 | ENSP00000283268 | ENSP00000379369 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | Forkhead box B1 | 0.455 |
| FEZF2 | OTP | ENSP00000283268 | ENSP00000302814 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | 0.671 |
| FEZF2 | OXT | ENSP00000283268 | ENSP00000217386 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin; Endogenous ligands | 0.442 |
| FEZF2 | POU3F2 | ENSP00000283268 | ENSP00000329170 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...] | 0.564 |
| FEZF2 | SIX3 | ENSP00000283268 | ENSP00000260653 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] | 0.645 |
| FOXB1 | FEZF2 | ENSP00000379369 | ENSP00000283268 | Forkhead box B1 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | 0.455 |
| FOXB1 | OTP | ENSP00000379369 | ENSP00000302814 | Forkhead box B1 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | 0.689 |
| FOXB1 | SIM1 | ENSP00000379369 | ENSP00000358210 | Forkhead box B1 | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult; Basic helix-loop-helix proteins | 0.551 |
| FOXB1 | SIM2 | ENSP00000379369 | ENSP00000290399 | Forkhead box B1 | Single-minded homolog 2; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development; Basic helix-loop-helix proteins | 0.415 |
| FOXB1 | SIX3 | ENSP00000379369 | ENSP00000260653 | Forkhead box B1 | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] | 0.426 |
| OTP | ACTR1A | ENSP00000302814 | ENSP00000358921 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.638 |
| OTP | ACTR1B | ENSP00000302814 | ENSP00000289228 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.650 |
| OTP | FEZF2 | ENSP00000302814 | ENSP00000283268 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | 0.671 |
| OTP | FOXB1 | ENSP00000302814 | ENSP00000379369 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | Forkhead box B1 | 0.689 |
| OTP | OXT | ENSP00000302814 | ENSP00000217386 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin; Endogenous ligands | 0.705 |
| OTP | POU3F2 | ENSP00000302814 | ENSP00000329170 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, (’GCAT’) and (’TAAT’), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL [...] | 0.632 |
