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STRINGSTRING
LEUTX LEUTX MPO MPO NR0B1 NR0B1 KHDC3L KHDC3L ZNF296 ZNF296 ERAS ERAS CLPTM1 CLPTM1 UTF1 UTF1 NKPD1 NKPD1 CLASRP CLASRP VSIG2 VSIG2
"ZNF296" - Zinc finger protein 296 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
ZNF296Zinc finger protein 296; May be a transcriptional corepressor with KLF4; Zinc fingers C2H2-type (475 aa)    
Predicted Functional Partners:
MPO
Myeloperoxidase; Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity; Belongs to the peroxidase family. XPO subfamily (745 aa)
            
  0.720
NKPD1
NTPase KAP family P-loop domain containing 1 (832 aa)
      
 
  0.679
KHDC3L
KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family (217 aa)
      
   
  0.608
CLASRP
CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity); Belongs to the splicing factor SR family (674 aa)
      
   
  0.605
ERAS
GTPase ERas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity); Belongs to the small GTPase superfamily. Ras family (233 aa)
      
 
  0.593
LEUTX
PRD class homeoboxes and pseudogenes (168 aa)
        
 
  0.586
NR0B1
Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity); Belongs to the nuclear hormone receptor family. NR0 subfamily (470 aa)
      
 
  0.579
CLPTM1
Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family (669 aa)
      
   
  0.563
UTF1
Undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2 (341 aa)
      
 
  0.555
VSIG2
V-set and immunoglobulin domain containing 2 (327 aa)
            
  0.515
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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