• Version:
  • 11.0 [archived version]
STRINGSTRING
CHST12 CHST12 SLC35E3 SLC35E3 LRRC57 LRRC57 ZNF556 ZNF556 ZNF474 ZNF474 TRIM28 TRIM28 SETDB1 SETDB1 YIPF4 YIPF4
"ZNF556" - Zinc finger protein 556 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF556Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type (456 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.935
LRRC57
Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 (239 aa)
     
 
  0.568
SLC35E3
Solute carrier family 35 member E3; Putative transporter; Solute carriers (313 aa)
     
   
  0.556
ZNF474
Zinc finger protein 474; Zinc fingers C2H2-type (364 aa)
           
  0.508
CHST12
Carbohydrate sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor; Belongs to the sulfotransferase 2 family (414 aa)
     
   
  0.458
YIPF4
Protein YIPF4; Involved in the maintenance of the Golgi structure; Belongs to the YIP1 family (244 aa)
     
   
  0.420
SETDB1
Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ t [...] (1291 aa)
     
 
  0.402
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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