node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHST12 | LRRC57 | ENSP00000481912 | ENSP00000326817 | Carbohydrate sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor; Belongs to the sulfotransferase 2 family | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | 0.409 |
CHST12 | ZNF556 | ENSP00000481912 | ENSP00000302603 | Carbohydrate sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor; Belongs to the sulfotransferase 2 family | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.458 |
LRRC57 | CHST12 | ENSP00000326817 | ENSP00000481912 | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | Carbohydrate sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor; Belongs to the sulfotransferase 2 family | 0.409 |
LRRC57 | SLC35E3 | ENSP00000326817 | ENSP00000381089 | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | Solute carrier family 35 member E3; Putative transporter; Solute carriers | 0.493 |
LRRC57 | ZNF556 | ENSP00000326817 | ENSP00000302603 | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.568 |
SETDB1 | TRIM28 | ENSP00000271640 | ENSP00000253024 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ t [...] | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.852 |
SETDB1 | ZNF556 | ENSP00000271640 | ENSP00000302603 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ t [...] | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.402 |
SLC35E3 | LRRC57 | ENSP00000381089 | ENSP00000326817 | Solute carrier family 35 member E3; Putative transporter; Solute carriers | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | 0.493 |
SLC35E3 | ZNF556 | ENSP00000381089 | ENSP00000302603 | Solute carrier family 35 member E3; Putative transporter; Solute carriers | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.556 |
TRIM28 | SETDB1 | ENSP00000253024 | ENSP00000271640 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ t [...] | 0.852 |
TRIM28 | ZNF556 | ENSP00000253024 | ENSP00000302603 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.935 |
YIPF4 | ZNF556 | ENSP00000238831 | ENSP00000302603 | Protein YIPF4; Involved in the maintenance of the Golgi structure; Belongs to the YIP1 family | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.420 |
ZNF474 | ZNF556 | ENSP00000296600 | ENSP00000302603 | Zinc finger protein 474; Zinc fingers C2H2-type | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.508 |
ZNF556 | CHST12 | ENSP00000302603 | ENSP00000481912 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Carbohydrate sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor; Belongs to the sulfotransferase 2 family | 0.458 |
ZNF556 | LRRC57 | ENSP00000302603 | ENSP00000326817 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | 0.568 |
ZNF556 | SETDB1 | ENSP00000302603 | ENSP00000271640 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ t [...] | 0.402 |
ZNF556 | SLC35E3 | ENSP00000302603 | ENSP00000381089 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Solute carrier family 35 member E3; Putative transporter; Solute carriers | 0.556 |
ZNF556 | TRIM28 | ENSP00000302603 | ENSP00000253024 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.935 |
ZNF556 | YIPF4 | ENSP00000302603 | ENSP00000238831 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein YIPF4; Involved in the maintenance of the Golgi structure; Belongs to the YIP1 family | 0.420 |
ZNF556 | ZNF474 | ENSP00000302603 | ENSP00000296600 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 474; Zinc fingers C2H2-type | 0.508 |