node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AVL9 | KBTBD2 | ENSP00000315568 | ENSP00000302586 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | Kelch repeat and BTB domain containing 2 | 0.778 |
AVL9 | RNF152 | ENSP00000315568 | ENSP00000316628 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating ’Lys-63’-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates ’Lys-48’-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed; Ring finger proteins | 0.724 |
AVL9 | RNF31 | ENSP00000315568 | ENSP00000315112 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | E3 ubiquitin-protein ligase RNF31; E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (’Met-1’-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF- [...] | 0.681 |
BBS9 | FKBP9 | ENSP00000242067 | ENSP00000439250 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing | 0.695 |
BBS9 | KBTBD2 | ENSP00000242067 | ENSP00000302586 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | Kelch repeat and BTB domain containing 2 | 0.687 |
BBS9 | NT5C3A | ENSP00000242067 | ENSP00000484415 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family | 0.562 |
BBS9 | RP9 | ENSP00000242067 | ENSP00000297157 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | Retinitis pigmentosa 9 protein; Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity) | 0.744 |
CUL3 | KBTBD2 | ENSP00000264414 | ENSP00000302586 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | Kelch repeat and BTB domain containing 2 | 0.655 |
FKBP9 | BBS9 | ENSP00000439250 | ENSP00000242067 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | 0.695 |
FKBP9 | KBTBD2 | ENSP00000439250 | ENSP00000302586 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing | Kelch repeat and BTB domain containing 2 | 0.725 |
FKBP9 | NT5C3A | ENSP00000439250 | ENSP00000484415 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing | Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family | 0.644 |
FKBP9 | RP9 | ENSP00000439250 | ENSP00000297157 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing | Retinitis pigmentosa 9 protein; Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity) | 0.731 |
KBTBD2 | AVL9 | ENSP00000302586 | ENSP00000315568 | Kelch repeat and BTB domain containing 2 | Late secretory pathway protein AVL9 homolog; Functions in cell migration | 0.778 |
KBTBD2 | BBS9 | ENSP00000302586 | ENSP00000242067 | Kelch repeat and BTB domain containing 2 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] | 0.687 |
KBTBD2 | CUL3 | ENSP00000302586 | ENSP00000264414 | Kelch repeat and BTB domain containing 2 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cu [...] | 0.655 |
KBTBD2 | FKBP9 | ENSP00000302586 | ENSP00000439250 | Kelch repeat and BTB domain containing 2 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing | 0.725 |
KBTBD2 | MANBA | ENSP00000302586 | ENSP00000226578 | Kelch repeat and BTB domain containing 2 | Beta-mannosidase; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides; Mannosidases type beta | 0.556 |
KBTBD2 | NT5C3A | ENSP00000302586 | ENSP00000484415 | Kelch repeat and BTB domain containing 2 | Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family | 0.698 |
KBTBD2 | PLD5 | ENSP00000302586 | ENSP00000440896 | Kelch repeat and BTB domain containing 2 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family | 0.545 |
KBTBD2 | RNF152 | ENSP00000302586 | ENSP00000316628 | Kelch repeat and BTB domain containing 2 | E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating ’Lys-63’-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates ’Lys-48’-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed; Ring finger proteins | 0.676 |