HSPBAP1 protein (human) - STRING database

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HSPBAP1

HSPB1-associated protein 1; May play a role in cellular stress response (488 aa)

Predicted Functional Partners:

HSPB1

0.832

HSPB2

0.816

C14orf169

0.805

JMJD4

0.805

DIRC3

0.800

HSPB3

0.767

OGFOD2

0.743

ARHGAP24

0.662

MARK1

0.662

DIRC2

0.645

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP24	HSPBAP1	ENSP00000378611	ENSP00000302562	Rho GTPase-activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamel [...]	HSPB1-associated protein 1; May play a role in cellular stress response	0.662
C14orf169	HSPBAP1	ENSP00000477507	ENSP00000302562	Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...]	HSPB1-associated protein 1; May play a role in cellular stress response	0.805
C14orf169	JMJD4	ENSP00000477507	ENSP00000355720	Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...]	JmjC domain-containing protein 4; Jumonji domain containing 4	0.809
C14orf169	OGFOD2	ENSP00000477507	ENSP00000380544	Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...]	2-oxoglutarate and iron dependent oxygenase domain containing 2	0.698
DIRC2	DIRC3	ENSP00000261038	ENSP00000389455	Disrupted in renal carcinoma protein 2; Electrogenic metabolite transporter; Belongs to the major facilitator superfamily	Disrupted in renal carcinoma 3	0.542
DIRC2	HSPBAP1	ENSP00000261038	ENSP00000302562	Disrupted in renal carcinoma protein 2; Electrogenic metabolite transporter; Belongs to the major facilitator superfamily	HSPB1-associated protein 1; May play a role in cellular stress response	0.645
DIRC3	DIRC2	ENSP00000389455	ENSP00000261038	Disrupted in renal carcinoma 3	Disrupted in renal carcinoma protein 2; Electrogenic metabolite transporter; Belongs to the major facilitator superfamily	0.542
DIRC3	HSPB1	ENSP00000389455	ENSP00000248553	Disrupted in renal carcinoma 3	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins	0.626
DIRC3	HSPB2	ENSP00000389455	ENSP00000302476	Disrupted in renal carcinoma 3	Heat shock protein beta-2; May regulate the kinase DMPK; Small heat shock proteins	0.641
DIRC3	HSPB3	ENSP00000389455	ENSP00000303394	Disrupted in renal carcinoma 3	Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins	0.574
DIRC3	HSPBAP1	ENSP00000389455	ENSP00000302562	Disrupted in renal carcinoma 3	HSPB1-associated protein 1; May play a role in cellular stress response	0.800
HSPB1	DIRC3	ENSP00000248553	ENSP00000389455	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins	Disrupted in renal carcinoma 3	0.626
HSPB1	HSPBAP1	ENSP00000248553	ENSP00000302562	Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins	HSPB1-associated protein 1; May play a role in cellular stress response	0.832
HSPB2	DIRC3	ENSP00000302476	ENSP00000389455	Heat shock protein beta-2; May regulate the kinase DMPK; Small heat shock proteins	Disrupted in renal carcinoma 3	0.641
HSPB2	HSPB3	ENSP00000302476	ENSP00000303394	Heat shock protein beta-2; May regulate the kinase DMPK; Small heat shock proteins	Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins	0.909
HSPB2	HSPBAP1	ENSP00000302476	ENSP00000302562	Heat shock protein beta-2; May regulate the kinase DMPK; Small heat shock proteins	HSPB1-associated protein 1; May play a role in cellular stress response	0.816
HSPB3	DIRC3	ENSP00000303394	ENSP00000389455	Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins	Disrupted in renal carcinoma 3	0.574
HSPB3	HSPB2	ENSP00000303394	ENSP00000302476	Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins	Heat shock protein beta-2; May regulate the kinase DMPK; Small heat shock proteins	0.909
HSPB3	HSPBAP1	ENSP00000303394	ENSP00000302562	Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins	HSPB1-associated protein 1; May play a role in cellular stress response	0.767
HSPBAP1	ARHGAP24	ENSP00000302562	ENSP00000378611	HSPB1-associated protein 1; May play a role in cellular stress response	Rho GTPase-activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamel [...]	0.662

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