| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ELANE | TPST1 | ENSP00000466090 | ENSP00000302413 | Neutrophil elastase; Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | 0.522 |
| OR9A4 | TPST1 | ENSP00000448789 | ENSP00000302413 | Olfactory receptor 9A4; Odorant receptor; Olfactory receptors, family 9 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | 0.499 |
| PODXL2 | SELPLG | ENSP00000345359 | ENSP00000228463 | Podocalyxin-like protein 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture; CD molecules | 0.491 |
| PODXL2 | TPST1 | ENSP00000345359 | ENSP00000302413 | Podocalyxin-like protein 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | 0.904 |
| PSG2 | TPST1 | ENSP00000385706 | ENSP00000302413 | Pregnancy specific beta-1-glycoprotein 2 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | 0.668 |
| PUSL1 | TPST1 | ENSP00000368318 | ENSP00000302413 | Pseudouridylate synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | 0.553 |
| PUSL1 | WDR33 | ENSP00000368318 | ENSP00000325377 | Pseudouridylate synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family | pre-mRNA 3’ end processing protein WDR33; Essential for both cleavage and polyadenylation of pre- mRNA 3’ ends; WD repeat domain containing | 0.642 |
| SBDS | TPST1 | ENSP00000246868 | ENSP00000302413 | Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell prolife [...] | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | 0.743 |
| SELPLG | PODXL2 | ENSP00000228463 | ENSP00000345359 | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture; CD molecules | Podocalyxin-like protein 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins | 0.491 |
| SELPLG | TPST1 | ENSP00000228463 | ENSP00000302413 | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture; CD molecules | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | 0.565 |
| SLC35B3 | TPST1 | ENSP00000368981 | ENSP00000302413 | Adenosine 3’-phospho 5’-phosphosulfate transporter 2; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon; Solute carriers | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | 0.685 |
| TPST1 | ELANE | ENSP00000302413 | ENSP00000466090 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | Neutrophil elastase; Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis | 0.522 |
| TPST1 | OR9A4 | ENSP00000302413 | ENSP00000448789 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | Olfactory receptor 9A4; Odorant receptor; Olfactory receptors, family 9 | 0.499 |
| TPST1 | PODXL2 | ENSP00000302413 | ENSP00000345359 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | Podocalyxin-like protein 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins | 0.904 |
| TPST1 | PSG2 | ENSP00000302413 | ENSP00000385706 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | Pregnancy specific beta-1-glycoprotein 2 | 0.668 |
| TPST1 | PUSL1 | ENSP00000302413 | ENSP00000368318 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | Pseudouridylate synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family | 0.553 |
| TPST1 | SBDS | ENSP00000302413 | ENSP00000246868 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell prolife [...] | 0.743 |
| TPST1 | SELPLG | ENSP00000302413 | ENSP00000228463 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture; CD molecules | 0.565 |
| TPST1 | SLC35B3 | ENSP00000302413 | ENSP00000368981 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | Adenosine 3’-phospho 5’-phosphosulfate transporter 2; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon; Solute carriers | 0.685 |
| TPST1 | WDR16 | ENSP00000302413 | ENSP00000339449 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family | Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival | 0.598 |
