| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C4BPA | SMR3B | ENSP00000356037 | ENSP00000302400 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.491 |
| C4BPA | STATH | ENSP00000356037 | ENSP00000246895 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface; Histatins and statherin | 0.670 |
| DNAJC21 | SMR3B | ENSP00000371451 | ENSP00000302400 | DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.424 |
| FBXO43 | SMR3B | ENSP00000403293 | ENSP00000302400 | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable); F-boxes other | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.420 |
| HSPB3 | SMR3B | ENSP00000303394 | ENSP00000302400 | Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.485 |
| LCN1 | SMR3B | ENSP00000263598 | ENSP00000302400 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.473 |
| MT-CO2 | SMR3B | ENSP00000354876 | ENSP00000302400 | Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.583 |
| MUC7 | SMR3B | ENSP00000407422 | ENSP00000302400 | Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili; Mucins | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.542 |
| MUC7 | STATH | ENSP00000407422 | ENSP00000246895 | Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili; Mucins | Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface; Histatins and statherin | 0.778 |
| SCGB1D4 | SMR3B | ENSP00000351395 | ENSP00000302400 | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.428 |
| SH3BP1 | SMR3B | ENSP00000350018 | ENSP00000302400 | SH3 domain-binding protein 1; GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specific [...] | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | 0.442 |
| SMR3B | C4BPA | ENSP00000302400 | ENSP00000356037 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | 0.491 |
| SMR3B | DNAJC21 | ENSP00000302400 | ENSP00000371451 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins | 0.424 |
| SMR3B | FBXO43 | ENSP00000302400 | ENSP00000403293 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable); F-boxes other | 0.420 |
| SMR3B | HSPB3 | ENSP00000302400 | ENSP00000303394 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins | 0.485 |
| SMR3B | LCN1 | ENSP00000302400 | ENSP00000263598 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket; Belongs to the calycin superfamily. Lipocalin family | 0.473 |
| SMR3B | MT-CO2 | ENSP00000302400 | ENSP00000354876 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1 | 0.583 |
| SMR3B | MUC7 | ENSP00000302400 | ENSP00000407422 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili; Mucins | 0.542 |
| SMR3B | SCGB1D4 | ENSP00000302400 | ENSP00000351395 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily | 0.428 |
| SMR3B | SH3BP1 | ENSP00000302400 | ENSP00000350018 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family | SH3 domain-binding protein 1; GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specific [...] | 0.442 |
