node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM11 | GABRD | ENSP00000200557 | ENSP00000367848 | Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.408 |
ADAM11 | LGI3 | ENSP00000200557 | ENSP00000302297 | Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | 0.676 |
ADAM22 | ADAM23 | ENSP00000265727 | ENSP00000264377 | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1; ADAM metallopeptidase domain containing | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | 0.912 |
ADAM22 | LGI3 | ENSP00000265727 | ENSP00000302297 | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1; ADAM metallopeptidase domain containing | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | 0.966 |
ADAM23 | ADAM22 | ENSP00000264377 | ENSP00000265727 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1; ADAM metallopeptidase domain containing | 0.912 |
ADAM23 | LGI3 | ENSP00000264377 | ENSP00000302297 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | 0.969 |
ADAM23 | SYT4 | ENSP00000264377 | ENSP00000255224 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | Synaptotagmin-4; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family | 0.576 |
ADAM28 | LGI3 | ENSP00000265769 | ENSP00000302297 | Disintegrin and metalloproteinase domain-containing protein 28; May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation; ADAM metallopeptidase domain containing | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | 0.604 |
GABRD | ADAM11 | ENSP00000367848 | ENSP00000200557 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | 0.408 |
GABRD | LGI3 | ENSP00000367848 | ENSP00000302297 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | 0.582 |
GABRD | PHYHIP | ENSP00000367848 | ENSP00000415491 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system | 0.488 |
LGI3 | ADAM11 | ENSP00000302297 | ENSP00000200557 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | 0.676 |
LGI3 | ADAM22 | ENSP00000302297 | ENSP00000265727 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1; ADAM metallopeptidase domain containing | 0.966 |
LGI3 | ADAM23 | ENSP00000302297 | ENSP00000264377 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | 0.969 |
LGI3 | ADAM28 | ENSP00000302297 | ENSP00000265769 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Disintegrin and metalloproteinase domain-containing protein 28; May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation; ADAM metallopeptidase domain containing | 0.604 |
LGI3 | GABRD | ENSP00000302297 | ENSP00000367848 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.582 |
LGI3 | MTUS1 | ENSP00000302297 | ENSP00000262102 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth; Belongs to the MTUS1 family | 0.624 |
LGI3 | PHYHIP | ENSP00000302297 | ENSP00000415491 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system | 0.577 |
LGI3 | STX1A | ENSP00000302297 | ENSP00000222812 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.915 |
LGI3 | STX1B | ENSP00000302297 | ENSP00000215095 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity); Belongs to the syntaxin family | 0.918 |