| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FGF8 | GBX2 | ENSP00000321797 | ENSP00000302251 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | 0.797 |
| FGF8 | IRX3 | ENSP00000321797 | ENSP00000331608 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | 0.452 |
| FGF8 | IRX6 | ENSP00000321797 | ENSP00000290552 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes | 0.427 |
| FGF8 | KLF4 | ENSP00000321797 | ENSP00000363804 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Krueppel-like factor 4; Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also fu [...] | 0.406 |
| FGF8 | LMX1B | ENSP00000321797 | ENSP00000347684 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | LIM homeobox transcription factor 1-beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels; LIM class homeoboxes | 0.685 |
| FGF8 | PAX2 | ENSP00000321797 | ENSP00000359319 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS; PRD class homeoboxes and pseudogenes | 0.811 |
| FGF8 | SIX3 | ENSP00000321797 | ENSP00000260653 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] | 0.759 |
| FGF8 | WNT1 | ENSP00000321797 | ENSP00000293549 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development | 0.859 |
| GBX2 | FGF8 | ENSP00000302251 | ENSP00000321797 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | 0.797 |
| GBX2 | IRX3 | ENSP00000302251 | ENSP00000331608 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | 0.614 |
| GBX2 | IRX6 | ENSP00000302251 | ENSP00000290552 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes | 0.624 |
| GBX2 | KLF4 | ENSP00000302251 | ENSP00000363804 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | Krueppel-like factor 4; Transcription factor; can act both as activator and as repressor. Binds the 5’-CACCC-3’ core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also fu [...] | 0.662 |
| GBX2 | LHX9 | ENSP00000302251 | ENSP00000356357 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | LIM/homeobox protein Lhx9; Involved in gonadal development; LIM class homeoboxes | 0.678 |
| GBX2 | LMX1B | ENSP00000302251 | ENSP00000347684 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | LIM homeobox transcription factor 1-beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels; LIM class homeoboxes | 0.616 |
| GBX2 | PAX2 | ENSP00000302251 | ENSP00000359319 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS; PRD class homeoboxes and pseudogenes | 0.826 |
| GBX2 | PAX5 | ENSP00000302251 | ENSP00000350844 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | Paired box protein Pax-5; May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene; PRD class homeoboxes and pseudogenes | 0.644 |
| GBX2 | SIX3 | ENSP00000302251 | ENSP00000260653 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] | 0.649 |
| GBX2 | WNT1 | ENSP00000302251 | ENSP00000293549 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development | 0.772 |
| IRX3 | FGF8 | ENSP00000331608 | ENSP00000321797 | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | 0.452 |
| IRX3 | GBX2 | ENSP00000331608 | ENSP00000302251 | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes | 0.614 |
